NDLI: Deficits in memory and hippocampal long-term potentiation in mice with reduced calbindin D28K expression.

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Deficits in memory and hippocampal long-term potentiation in mice with reduced calbindin D28K expression.

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Deficits in memory and hippocampal long-term potentiation in mice with reduced calbindin D28K expression.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Robbins, T. W. Battini, R. Pozzi, L. Killcross, A. S. Ferrari, S. Billard, J. M. Dutar, P. Lamour, Y. Baker, W. A. Emson, P. C. Jouvenceau, A. Cox, H. Molinari, S.
Description	Author Affiliation: Molinari S ( Dipartimento di Scienze Biomediche, Sezione di Chimica Biologica, Universita di Modena, Italy.);
Abstract	The influx of calcium into the postsynaptic neuron is likely to be an important event in memory formation. Among the mechanisms that nerve cells may use to alter the time course or size of a spike of intracellular calcium are cytosolic calcium binding or 'buffering' proteins. To consider the role in memory formation of one of these proteins, calbindin D28K, which is abundant in many neurons, including the CA1 pyramidal cells of the hippocampus, transgenic mice deficient in calbindin D28K have been created. These mice show selective impairments in spatial learning paradigms and fail to maintain long-term potentiation. These results suggest a role for calbindin D28K protein in temporally extending a neuronal calcium signal, allowing the activation of calcium-dependent intracellular signaling pathways underlying memory function.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	15
Volume Number	93
Language	English
Publisher	National Academy of Sciences
Publisher Date	1996-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Hippocampus Physiology Long-Term Potentiation Maze Learning Memory Nerve Tissue Proteins Biosynthesis Neurons S100 Calcium Binding Protein G Animals Calbindin 1 Calbindins DNA, Antisense DNA, Complementary Discrimination (Psychology) Electric Stimulation In Vitro Techniques Memory Disorders Genetics Physiopathology Mice Mice, Transgenic Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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