NDLI: A Ds insertion alters the nuclear localization of the maize transcriptional activator R.

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A Ds insertion alters the nuclear localization of the maize transcriptional activator R.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Alleman, M. Liu, Y. Wessler, S. R.
Description	Author Affiliation: Liu Y ( Department of Botany, University of Georgia, Athens 30602, USA.);
Abstract	The R-sc gene of maize is a member of the R gene family of transcriptional activators that regulate anthocyanin biosynthesis. A derivative of R-sc, r-m9 conditions a reduced level of aleurone pigmentation due to the presence of a 2.1-kb Ds insertion near the 3' end of the coding region. Excision of Ds from r-m9 leaves a 7-bp insertion in the darker but still mutant v24 derivative. Both the 7-bp insertion in v24 and the 2.1-kb Ds in r-m9 are predicted to truncate their respective R proteins proximal to the carboxyl terminus, which was shown previously to contain one of three nuclear localization sequences. We find that the reduced expression of r-m9 and v24 are not due to mRNA or protein instability, but most likely reflect the inefficient localization of truncated R proteins to the nucleus. To our knowledge this is the first example of a transposable element insertion that alters gene expression by affecting nuclear localization. In addition, our data indicate that the carboxyl terminus of the R protein is far more important than previously suspected and illustrates the utility of natural mutations for defining functional domains in proteins.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	15
Volume Number	93
Language	English
Publisher	National Academy of Sciences
Publisher Date	1996-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cell Nucleus Metabolism DNA Transposable Elements Multigene Family Plant Proteins Trans-Activators Biosynthesis Zea Mays Genetics Amino Acid Sequence Anthocyanins Blotting, Western DNA Primers Genes, Plant Molecular Sequence Data Mutagenesis, Insertional Polymerase Chain Reaction RNA, Plant Transcription, Genetic Research Support, U.S. Gov't, Non-P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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