NDLI: Expression of hyaluronidase by tumor cells induces angiogenesis in vivo.

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The best thermoelectric.

Multicomponent diffusion in polymeric liquids.

A meta-analysis of the freshwater trophic cascade.

Error-prone retrotransposition: rime of the ancient mutators.

Second-hand chloroplasts and the case of the disappearing nucleus.

Photo-induced inactivation of viruses: adsorption of methylene blue, thionine, and thiopyronine on Qbeta bacteriophage.

Persistent confusion of total entropy and chemical system entropy in chemical thermodynamics.

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In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains.

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Expression of hyaluronidase by tumor cells induces angiogenesis in vivo.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Mori, H. Diaconu, E. Willson, J. Guo, K. Pearlman, E. Liu, D. Sy, M. S. Haqqi, T. Markowitz, S.
Description	Author Affiliation: Liu D ( Institute of Pathology, Cancer Research Institute, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.);
Abstract	Hyaluronic acid is a proteoglycan present in the extracellular matrix and is important for the maintenance of tissue architecture. Depolymerization of hyaluronic acid may facilitate tumor invasion. In addition, oligosaccharides of hyaluronic acid have been reported to induce angiogenesis. We report here that a hyaluronidase similar to the one on human sperm is expressed by metastatic human melanoma, colon carcinoma, and glioblastoma cell lines and by tumor biopsies from patients with colorectal carcinomas, but not by tissues from normal colon. Moreover, angiogenesis is induced by hyaluronidase+ tumor cells but not hyaluronidase- tumor cells and can be blocked by an inhibitor of hyaluronidase. Tumor cells thus use hyaluronidase as one of the 'molecular saboteurs' to depolymerize hyaluronic acid to facilitate invasion. As a consequence, breakdown products of hyaluronic acid can further promote tumor establishment by inducing angiogenesis. Hyaluronidase on tumor cells may provide a target for anti-neoplastic drugs.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	15
Volume Number	93
Language	English
Publisher	National Academy of Sciences
Publisher Date	1996-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Hyaluronoglucosaminidase Biosynthesis Melanoma Blood Supply Enzymology Neovascularization, Pathologic Animals Cell Division Drug Effects Chamomile Colonic Neoplasms Cornea DNA Primers Enzyme Inhibitors Pharmacology Flavonoids Glioblastoma Glioma Antagonists & Inhibitors Pathology Mice Mice, Inbred BALB C Molecular Sequence Data Neoplasm Invasiveness Neoplasm Metastasis Oils, Volatile Plants, Medicinal Polymerase Chain Reaction RNA, Messenger Time Factors Transcription, Genetic Transplantation, Heterologous Tumor Cells, Cultured Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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