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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Bocchietto, E. Di Renzo, M. F. Comoglio, P. M. Olivero, M. Coffer, A. Bussolino, F. Ziche, M. Naldini, L. Tamagnone, L. Gaudino, G. |
| Description | Author Affiliation: Bussolino F ( Department of Genetics, Biology and Medical Chemistry, University of Torino.) |
| Abstract | Hepatocyte Growth Factor (HGF, also known as Scatter Factor) is a powerful mitogen or motility factor in different cells, acting through the tyrosine kinase receptor encoded by the MET protooncogene. Endothelial cells express the MET gene and expose at the cell surface the mature protein (p190MET) made of a 50 kD (alpha) subunit disulfide linked to a 145-kD (beta) subunit. HGF binding to endothelial cells identifies two sites with different affinities. The higher affinity binding site (Kd = 0.35 nM) corresponds to the p190MET receptor. Sub- nanomolar concentrations of HGF, but not of a recombinant inactive precursor, stimulate the receptor kinase activity, cell proliferation and motility. HGF induces repairs of a wound in endothelial cell monolayer. HGF stimulates the scatter of endothelial cells grown on three-dimensional collagen gels, inducing an elongated phenotype. In the rabbit cornea, highly purified HGF promotes neovascularization at sub-nanomolar concentrations. HGF lacks activities related to hemostasis-thrombosis, inflammation and endothelial cells accessory functions. These data show that HGF is an in vivo potent angiogenic factor and in vitro induces endothelial cells to proliferate and migrate. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 3 |
| Volume Number | 119 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 1992-11-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Cell Movement Drug Effects Endothelium, Vascular Physiology Hepatocyte Growth Factor Metabolism Pharmacology Neovascularization, Pathologic Protein-Tyrosine Kinases Proto-Oncogene Proteins Wound Healing Animals Cell Line Cells, Cultured Cornea Cytology Genetics Kinetics Macromolecular Substances Mice Mutagenesis, Site-Directed Proto-Oncogene Proteins C-met Proto-Oncogenes Rabbits Recombinant Proteins Umbilical Veins Research Support, Non-U.S. Gov't Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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