NDLI: Sarcoplasmic reticulum $Ca^{2+}$ release flux underlying $Ca^{2+}$ sparks in cardiac muscle

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Sarcoplasmic reticulum $Ca^{2+}$ release flux underlying $Ca^{2+}$ sparks in cardiac muscle

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Sarcoplasmic reticulum $Ca^{2+}$ release flux underlying $Ca^{2+}$ sparks in cardiac muscle

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hüser, J. Ríos, E. Blatter, L. A.
Description	Author Affiliation: Blatter LA ( Department of Physiology, Loyola University Chicago, Maywood, IL 60153, USA.);
Abstract	Discrete events of Ca2+ release from the sarcoplasmic reticulum (SR) have been described in cardiac, skeletal, and smooth muscle. In skeletal muscle these release events originate at individual channels. In cardiac muscle, however, it remains a question of debate whether localized Ca2+ release transients, termed Ca2+ sparks, originate from single release channels or multiple channels clustered in close vicinity. Generalizing methods used earlier to describe cell-averaged Ca2+ release, we derived, as a function of space and time, the flux of Ca2+ release that underlies Ca2+ sparks. Using the method to analyze spontaneous sparks recorded with confocal microscopy in dissociated cat atrial cells, we obtained in most cases single sparks of Ca2+ release that appear to originate from approximately 1-microm-wide regions. In many cases, doublets, triplets, and greater groups of release sparks were observed. This multiplicity, the estimated release flux magnitude, and existing data on the structure of junctions between SR and plasmalemma suggest that individual release sparks result from the opening of multiple Ca2+ release channels clustered within discrete SR junctional regions.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	8
Volume Number	94
Language	English
Publisher	National Academy of Sciences
Publisher Date	1997-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Calcium Metabolism Heart Physiology Myocardial Contraction Sarcoplasmic Reticulum Animals Cells, Cultured Electrophysiology Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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