NDLI: Nucleolin is one component of the B cell-specific transcription factor and switch region binding protein, LR1.

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Nucleolin is one component of the B cell-specific transcription factor and switch region binding protein, LR1.

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Nucleolin is one component of the B cell-specific transcription factor and switch region binding protein, LR1.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Maizels, N. Hanakahi, L. A. Dempsey, L. A. Li, M. J.
Description	Author Affiliation: Hanakahi LA ( Department of Molecular Biophysics, Yale University, New Haven, CT 06520-8114, USA.);
Abstract	LR1 is a B cell-specific, sequence-specific DNA binding activity that regulates transcription in activated B cells. LR1 also binds Ig heavy chain switch region sequences and may function in class switch recombination. LR1 contains two polypeptides, of 106 kDa and 45 kDa, and here we report that the 106-kDa component of LR1 is nucleolin. This identification, initially made by microsequence analysis, was verified by showing that (i) LR1-DNA binding activity increased in B cells transfected with a nucleolin cDNA expression construct; (ii) LR1-DNA binding activity was recognized by antibodies raised against recombinant human nucleolin; and (iii) in B cells transfected with epitope-tagged nucleolin expression constructs, the LR1-DNA complex was recognized by the anti-tag antibody. Nucleolin is an abundant nucleolar protein which is believed to play a role in rDNA transcription or organization, or rRNA processing. Homology between nucleolin and histone H1 suggests that nucleolin may alter DNA organization in response to cell cycle controls, and the nucleolin component of LR1 may therefore function to organize switch regions before, during, or after switch recombination. The demonstration that nucleolin is a component of a B cell-specific complex that binds switch region sequences suggests that the G-rich switch regions may have evolved from rDNA.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	8
Volume Number	94
Language	English
Publisher	National Academy of Sciences
Publisher Date	1997-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	B-Lymphocytes Immunology DNA-Binding Proteins Genetics Immunoglobulin Switch Region Nuclear Proteins Phosphoproteins RNA-Binding Proteins Transcription Factors Amino Acid Sequence Animals Cell Line Immunoglobulin Class Switching Mice Molecular Sequence Data Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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