NDLI: Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance.

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Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance.

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Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Arriza, J. L. Kavanaugh, M. P. Eliasof, S. Amara, S. G.
Description	Author Affiliation: Arriza JL ( Vollum Institute for Advanced Biomedical Research, Oregon Health Sciences University, Portland 97210, USA.);
Abstract	Although a glutamate-gated chloride conductance with the properties of a sodium-dependent glutamate transporter has been described in vertebrate retinal photoreceptors and bipolar cells, the molecular species underlying this conductance has not yet been identified. We now report the cloning and functional characterization of a human excitatory amino acid transporter, EAAT5, expressed primarily in retina. Although EAAT5 shares the structural homologies of the EAAT gene family, one novel feature of the EAAT5 sequence is a carboxy-terminal motif identified previously in N-methyl-D-aspartate receptors and potassium channels and shown to confer interactions with a family of synaptic proteins that promote ion channel clustering. Functional properties of EAAT5 were examined in the Xenopus oocyte expression system by measuring radiolabeled glutamate flux and two-electrode voltage clamp recording. EAAT5-mediated L-glutamate uptake is sodium- and voltage-dependent and chloride-independent. Transporter currents elicited by glutamate are also sodium- and voltage-dependent, but ion substitution experiments suggest that this current is largely carried by chloride ions. These properties of EAAT5 are similar to the glutamate-elicited chloride conductances previously described in retinal neurons, suggesting that the EAAT5-associated chloride conductance may participate in visual processing.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	8
Volume Number	94
Language	English
Publisher	National Academy of Sciences
Publisher Date	1997-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Amino Acid Transport Systems Carrier Proteins Genetics Chlorides Metabolism Photoreceptor Cells Retina Amino Acid Sequence Animals Isolation & Purification Cloning, Molecular Excitatory Amino Acid Transporter 5 Ion Transport Molecular Sequence Data Urodela Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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