NDLI: The myosin-I-binding protein Acan125 binds the SH3 domain and belongs to the superfamily of leucine-rich repeat proteins

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1997 Volume: 94 Issue: 26

Year: 1997 Volume: 94 Issue: 25

Year: 1997 Volume: 94 Issue: 24

Year: 1997 Volume: 94 Issue: 23

Year: 1997 Volume: 94 Issue: 22

Year: 1997 Volume: 94 Issue: 21

Year: 1997 Volume: 94 Issue: 20

Year: 1997 Volume: 94 Issue: 19

Year: 1997 Volume: 94 Issue: 18

Year: 1997 Volume: 94 Issue: 17

Year: 1997 Volume: 94 Issue: 16

Year: 1997 Volume: 94 Issue: 15

Year: 1997 Volume: 94 Issue: 14

Year: 1997 Volume: 94 Issue: 13

Year: 1997 Volume: 94 Issue: 12

Year: 1997 Volume: 94 Issue: 11

Year: 1997 Volume: 94 Issue: 10

Year: 1997 Volume: 94 Issue: 9

Year: 1997 Volume: 94 Issue: 8

Seeking the root of insect resistance to transgenic plants.

Is RecF a DNA replication protein?

Origin of antifreeze protein genes: a cool tale in molecular evolution.

Directionality principles in thermodynamics and evolution.

On the difference in ionization properties between planar interfaces and linear polyelectrolytes.

Gas-phase $NO^{+} affinities$

Oat-maize chromosome addition lines: a new system for mapping the maize genome.

Site-directed mutagenesis of amino acid residues of protein phosphatase 1 involved in catalysis and inhibitor binding

Characterization of the interaction between DARPP-32 and protein phosphatase 1 (PP-1): DARPP-32 peptides antagonize the interaction of PP-1 with binding proteins.

Nuclear antisense RNA induces extensive adenosine modifications and nuclear retention of target transcripts.

An inhibitor of the Tat/TAR RNA interaction that effectively suppresses HIV-1 replication.

Conservation of function between mammalian and plant steroid 5alpha-reductases.

The basic helix-loop-helix transcription factor BETA2/NeuroD is expressed in mammalian enteroendocrine cells and activates secretin gene expression.

Engineering unnatural nucleotide specificity for Rous sarcoma virus tyrosine kinase to uniquely label its direct substrates.

A structural model for GroEL-polypeptide recognition.

Refolding chromatography with immobilized mini-chaperones.

$AlF_{3}$ mimics the transition state of protein phosphorylation in the crystal structure of nucleoside diphosphate kinase and MgADP

Crystal structure of Lyme disease antigen outer surface protein A complexed with an Fab.

Src regulated by C-terminal phosphorylation is monomeric

RNA splicing specificity determined by the coordinated action of RNA recognition motifs in SR proteins

Zeste-mediated activation by an enhancer is independent of cooperative DNA binding in vivo.

Nucleolin is one component of the B cell-specific transcription factor and switch region binding protein, LR1.

Infrared spectral models demonstrate that exposure to environmental chemicals leads to new forms of DNA

Design of TATA box-binding protein/zinc finger fusions for targeted regulation of gene expression.

The mechanism of thioredoxin reductase from human placenta is similar to the mechanisms of lipoamide dehydrogenase and glutathione reductase and is distinct from the mechanism of thioredoxin reductase from Escherichia coli.

Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase.

AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1.

ELL2, a new member of an ELL family of RNA polymerase II elongation factors.

Direct mapping of an agonist-binding domain within the parathyroid hormone/parathyroid hormone-related protein receptor by photoaffinity crosslinking.

Identification of sulfated oligosialic acid units in the O-linked glycan of the sea urchin egg receptor for sperm.

The large subunit of RNA polymerase II is a substrate of the Rsp5 ubiquitin-protein ligase.

Human TAF(II)28 interacts with the human T cell leukemia virus type I Tax transactivator and promotes its transcriptional activity.

Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis.

Buried asparagines determine the dimerization specificities of leucine zipper mutants.

The T/t common exon of simian virus 40, JC, and BK polyomavirus T antigens can functionally replace the J-domain of the Escherichia coli DnaJ molecular chaperone.

The myosin-I-binding protein Acan125 binds the SH3 domain and belongs to the superfamily of leucine-rich repeat proteins

Changing the mechanism of transcriptional activation by phage lambda repressor.

Yeast hormone response element assays detect and characterize GRIP1 coactivator-dependent activation of transcription by thyroid and retinoid nuclear receptors.

Effect of protein dynamics on biological electron transfer.

Fast events in protein folding: relaxation dynamics of secondary and tertiary structure in native apomyoglobin.

recF and recR are required for the resumption of replication at DNA replication forks in Escherichia coli.

Regulated bidirectional motility of melanophore pigment granules along microtubules in vitro.

A mathematical model of the cytosolic-free calcium response in endothelial cells to fluid shear stress.

Resinless section electron microscopy reveals the yeast cytoskeleton.

RanBP2 associates with Ubc9p and a modified form of RanGAP1.

Nuclear translocation of mitogen-activated protein kinase kinase (MEK1) in response to mitogenic stimulation

Generation of Alzheimer beta-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation.

Caveolin mRNA levels are up-regulated by free cholesterol and down-regulated by oxysterols in fibroblast monolayers.

Bcl-x(L) can inhibit apoptosis in cells that have undergone Fas-induced protease activation.

Mutagenic effects of a single and an exact number of alpha particles in mammalian cells.

Arachidonic acid activates c-jun N-terminal kinase through NADPH oxidase in rabbit proximal tubular epithelial cells.

Insulin-like growth factor II stimulates cell proliferation through the insulin receptor.

Retrograde transport of mutant ricin to the endoplasmic reticulum with subsequent translocation to cytosol.

Disruption of overlapping transcripts in the ROSA beta geo 26 gene trap strain leads to widespread expression of beta-galactosidase in mouse embryos and hematopoietic cells.

Glucose transporter GLUT3: ontogeny, targeting, and role in the mouse blastocyst.

Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality.

Creation of libraries with long ORFs by polymerization of a microgene.

Evolution of antifreeze glycoprotein gene from a trypsinogen gene in Antarctic notothenioid fish.

Convergent evolution of antifreeze glycoproteins in Antarctic notothenioid fish and Arctic cod.

Genomic mutation rates for lifetime reproductive output and lifespan in Caenorhabditis elegans.

The role of habitat shift in the evolution of lizard morphology: evidence from tropical Tropidurus.

Avian vocalizations and phylogenetic signal.

Gypsy retrotransposon as a tool for the in vivo analysis of the regulatory region of the optomotor-blind gene in Drosophila.

The nude gene encodes a sequence-specific DNA binding protein with homologs in organisms that lack an anticipatory immune system.

Expression of RBM in the nuclei of human germ cells is dependent on a critical region of the Y chromosome long arm.

Specific chromosomal imbalances in human papillomavirus-transfected cells during progression toward immortality.

RecQ DNA helicase is a suppressor of illegitimate recombination in Escherichia coli.

C-terminal deletion mutant of pokeweed antiviral protein inhibits viral infection but does not depurinate host ribosomes.

Genotypes at the GluR6 kainate receptor locus are associated with variation in the age of onset of Huntington disease.

Dissection of a circadian oscillation into discrete domains.

Oxidative stress mediates impairment of muscle function in transgenic mice with elevated level of wild-type Cu/Zn superoxide dismutase

The k43 gene, required for chorion gene amplification and diploid cell chromosome replication, encodes the Drosophila homolog of yeast origin recognition complex subunit 2.

Cytosine methylation determines hot spots of DNA damage in the human P53 gene.

The partial tandem duplication of ALL1 in acute myeloid leukemia with normal cytogenetics or trisomy 11 is restricted to one chromosome.

Subtractive isolation of phage-displayed single-chain antibodies to thymic stromal cells by using intact thymic fragments.

Antigen receptor engagement delivers a stop signal to migrating T lymphocytes.

Polymorphism of murine Fas ligand that affects the biological activity

Functional differentiation of T cells in the intestine of T cell receptor transgenic mice.

In vitro restoration of T cell responses in tuberculosis and augmentation of monocyte effector function against Mycobacterium tuberculosis by natural inhibitors of transforming growth factor beta.

'Autoimmune rejection' of neonatal heart transplants in experimental Chagas disease is a parasite-specific response to infected host tissue.

Bruton's tyrosine kinase regulates apoptosis and JNK/SAPK kinase activity.

Transgenic expression of CD95 ligand on islet beta cells induces a granulocytic infiltration but does not confer immune privilege upon islet allografts.

Interleukin 18 together with interleukin 12 inhibits IgE production by induction of interferon-gamma production from activated B cells.

Astrocyte apoptosis induced by HIV-1 transactivation of the c-kit protooncogene.

The rotavirus enterotoxin NSP4 mobilizes intracellular calcium in human intestinal cells by stimulating phospholipase C-mediated inositol 1,4,5-trisphosphate production

Antileukemia effect of c-myc N3'-->P5' phosphoramidate antisense oligonucleotides in vivo.

Correlation of germ-line mutations and two-hit inactivation of the WT1 gene with Wilms tumors of stromal-predominant histology.

Arsenic-induced PML targeting onto nuclear bodies: implications for the treatment of acute promyelocytic leukemia.

Unique features in the structure of the complex between HIV-1 reverse transcriptase and the bis(heteroaryl)piperazine (BHAP) U-90152 explain resistance mutations for this nonnucleoside inhibitor.

Transgenic rescue from embryonic lethality and renal carcinogenesis in the Eker rat model by introduction of a wild-type Tsc2 gene.

Chondrocytes as a specific target of ectopic Fos expression in early development.

Synergy of Taxol and radioimmunotherapy with yttrium-90-labeled chimeric L6 antibody: efficacy and toxicity in breast cancer xenografts.

Differential utilization of CCR5 by macrophage and T cell tropic simian immunodeficiency virus strains.

Hematopoietic activity of a stromal cell transmembrane protein containing epidermal growth factor-like repeat motifs.

KvLQT1, a voltage-gated potassium channel responsible for human cardiac arrhythmias

Signal transduction in macrophages by glycosylphosphatidylinositols of Plasmodium, Trypanosoma, and Leishmania: activation of protein tyrosine kinases and protein kinase C by inositolglycan and diacylglycerol moieties.

Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins.

P1,P4-dithio-P2,P3-monochloromethylene diadenosine 5',5'''-P1,P4-tetraphosphate: a novel antiplatelet agent.

A new approach to determining the rates of recruitment of circulating leukocytes into tissues: application to the measurement of leukocyte recruitment into atherosclerotic lesions.

Replication synchrony-PCR: a sampling-time-independent assay for replication synchrony in human tissues and tumors in situ.

N-terminal sequences from Autographa californica nuclear polyhedrosis virus envelope proteins ODV-E66 and ODV-E25 are sufficient to direct reporter proteins to the nuclear envelope, intranuclear microvesicles and the envelope of occlusion derived virus.

A diffusible cytotoxin of Haemophilus ducreyi.

Vaccine effect using a live attenuated nef-deficient simian immunodeficiency virus of African green monkeys in the absence of detectable vaccine virus replication in vivo.

A permeabilized cell system that assembles filamentous bacteriophage.

Stoichiometric packaging of the three genomic segments of double-stranded RNA bacteriophage phi6.

Hematopoietic cells differentiate into both microglia and macroglia in the brains of adult mice.

Rapid suppression of free radical formation by nerve growth factor involves the mitogen-activated protein kinase pathway.

Rhythms of Drosophila period gene expression in culture.

Motor-driven gene expression.

Genetic determinants of susceptibility to excitotoxic cell death: implications for gene targeting approaches.

Disaggregation of Alzheimer beta-amyloid by site-directed mAb.

Familial multiple system tauopathy with presenile dementia: a disease with abundant neuronal and glial tau filaments.

Emotion, olfaction, and the human amygdala: amygdala activation during aversive olfactory stimulation.

Intracellular and secreted Alzheimer beta-amyloid species are generated by distinct mechanisms in cultured hippocampal neurons.

Conserved and sexually dimorphic behavioral responses to biogenic amines in decapitated Drosophila.

A protein factor that inhibits ATP-dependent glutamate and gamma-aminobutyric acid accumulation into synaptic vesicles: purification and initial characterization.

Mice devoid of gamma-aminobutyrate type A receptor beta3 subunit have epilepsy, cleft palate, and hypersensitive behavior.

Target-independent cholinergic differentiation in the rat sympathetic nervous system.

Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance.

Distinct forms of short-term plasticity at excitatory synapses of hippocampus and neocortex.

A substance P antagonist, RP-67,580, ameliorates a mouse meningoencephalitic response to Trypanosoma brucei brucei.

Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus.

Sarcoplasmic reticulum $Ca^{2+}$ release flux underlying $Ca^{2+}$ sparks in cardiac muscle

Suppression of voltage-gated L-type $Ca^{2+}currents$ by polyunsaturated fatty acids in adult and neonatal rat ventricular myocytes

Changes in anandamide levels in mouse uterus are associated with uterine receptivity for embryo implantation.

Nitric oxide is the mediator of both endothelium-dependent relaxation and hyperpolarization of the rabbit carotid artery.

Estrogen regulates the rate of bone turnover but bone balance in ovariectomized rats is modulated by prevailing mechanical strain.

Adult fast myosin pattern and $Ca^{2+}-induced$ slow myosin pattern in primary skeletal muscle culture

Expression of a borage desaturase cDNA containing an N-terminal cytochrome b5 domain results in the accumulation of high levels of delta6-desaturated fatty acids in transgenic tobacco.

Evidence for a common sex determination mechanism for pistil abortion in maize and in its wild relative Tripsacum.

Fertilization-independent seed development in Arabidopsis thaliana.

Year: 1997 Volume: 94 Issue: 7

Year: 1997 Volume: 94 Issue: 6

Year: 1997 Volume: 94 Issue: 5

Year: 1997 Volume: 94 Issue: 4

Year: 1997 Volume: 94 Issue: 3

Year: 1997 Volume: 94 Issue: 2

Year: 1997 Volume: 94 Issue: 1

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

The myosin-I-binding protein Acan125 binds the SH3 domain and belongs to the superfamily of leucine-rich repeat proteins

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Xu, P. Kemp, B. E. Zot, H. G. Kobe, B. Mitchelhill, K. I.
Description	Author Affiliation: Xu P ( Department of Physiology, University of Texas Southwestern Medical Center at Dallas, 75235-9040, USA.);
Abstract	The SH3 domains of src and other nonreceptor tyrosine kinases have been shown to associate with the motif PXXP, where P and X stand for proline and an unspecified amino acid, but a motif that binds to the SH3 domain of myosin has thus far not been characterized. We previously showed that the SH3 domain of Acanthamoeba myosin-IC interacts with the protein Acan125. We now report that the Acan125 protein sequence contains two tandem consensus PXXP motifs near the C terminus. To test for binding, we expressed a polypeptide, AD3p, which includes 344 residues of native C-terminal sequence and a mutant polypeptide, AD3delta977-994p, which lacks the sequence RPKPVPPPRGAKPAPPPR containing both PXXP motifs. The SH3 domain of Acanthamoeba myosin-IC bound AD3p and not AD3delta977-994p, showing that the PXXP motifs are required for SH3 binding. The sequence of Acan125 is related overall to a protein of unknown function coded by Caenorhabditis elegans gene K07G5.1. The K07G5.1 gene product contains a proline-rich segment similar to the SH3 binding motif found in Acan125. The aligned sequences show considerable conservation of leucines and other hydrophobic residues, including the spacing of these residues, which matches a motif for leucine-rich repeats (LRRs). LRR domains have been demonstrated to be sites for ligand binding. Having an LRR domain and an SH3-binding domain, Acan125 and the C. elegans homologue define a novel family of bifunctional binding proteins.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	8
Volume Number	94
Language	English
Publisher	National Academy of Sciences
Publisher Date	1997-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Carrier Proteins Metabolism Leucine Genetics Proto-Oncogene Proteins Pp60(c-src) Protozoan Proteins Acanthamoeba Amino Acid Sequence Animals Molecular Sequence Data Repetitive Sequences, Nucleic Acid Sequence Alignment Research Support, U.S. Gov't, Non-P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in