NDLI: recF and recR are required for the resumption of replication at DNA replication forks in Escherichia coli.

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recF and recR are required for the resumption of replication at DNA replication forks in Escherichia coli.

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recF and recR are required for the resumption of replication at DNA replication forks in Escherichia coli.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hanawalt, P. C. Carswell-crumpton, C. Courcelle, J.
Description	Author Affiliation: Courcelle J ( Department of Biological Sciences, Stanford University, CA 94305-5020, USA. jcc@leland.stanford.edu);
Abstract	Escherichia coli containing a mutation in recF are hypersensitive to UV. However, they exhibit normal levels of conjugational or transductional recombination unless the major pathway (recBC) is defective. This implies that the UV sensitivity of recF mutants is not due to a defect in recombination such as occurs during conjugation or transduction. Here, we show that when replication is disrupted, at least two genes in the recF pathway, recF and recR, are required for the resumption of replication at DNA replication forks, and that in their absence, localized degradation occurs at the replication forks. Our observations support a model in which recF and recR are required to reassemble a replication holoenzyme at the site of a DNA replication fork. These results, when taken together with previous literature, suggest that the UV hypersensitivity of recF cells is due to an inability to resume replication at disrupted replication forks rather than to a defect in recombination. Current biochemical and genetic data on the conditions under which recF-mediated recombination occurs suggest that the recombinational intermediate also may mimic the structure of a disrupted replication fork.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	8
Volume Number	94
Language	English
Publisher	National Academy of Sciences
Publisher Date	1997-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Bacterial Proteins Genetics DNA Replication DNA, Bacterial DNA-Binding Proteins Escherichia Coli Proteins Escherichia Coli Recombination, Genetic Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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