NDLI: Tumorigenic conversion of immortal human keratinocytes through stromal cell activation.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1998 Volume: 95 Issue: 26

Year: 1998 Volume: 95 Issue: 25

Year: 1998 Volume: 95 Issue: 24

Year: 1998 Volume: 95 Issue: 23

Year: 1998 Volume: 95 Issue: 22

Year: 1998 Volume: 95 Issue: 21

Year: 1998 Volume: 95 Issue: 20

Year: 1998 Volume: 95 Issue: 19

Year: 1998 Volume: 95 Issue: 18

Year: 1998 Volume: 95 Issue: 17

Year: 1998 Volume: 95 Issue: 16

Year: 1998 Volume: 95 Issue: 15

Year: 1998 Volume: 95 Issue: 14

Year: 1998 Volume: 95 Issue: 13

Year: 1998 Volume: 95 Issue: 12

Year: 1998 Volume: 95 Issue: 11

Year: 1998 Volume: 95 Issue: 10

Year: 1998 Volume: 95 Issue: 9

Year: 1998 Volume: 95 Issue: 8

Year: 1998 Volume: 95 Issue: 7

Year: 1998 Volume: 95 Issue: 6

Year: 1998 Volume: 95 Issue: 5

Year: 1998 Volume: 95 Issue: 4

Year: 1998 Volume: 95 Issue: 3

The neuroimaging of human brain function.

Behind the scenes of functional brain imaging: a historical and physiological perspective.

Event-related functional MRI: past, present, and future.

Event-related brain potentials in the study of visual selective attention.

Functional and structural mapping of human cerebral cortex: solutions are in the surfaces.

Imaging neuroscience: principles or maps?

Spatially independent activity patterns in functional MRI data during the stroop color-naming task.

Functional analysis of primary visual cortex (V1) in humans.

The representation of the ipsilateral visual field in human cerebral cortex.

On the role of selective attention in visual perception.

Frontoparietal cortical networks for directing attention and the eye to visual locations: identical, independent, or overlapping neural systems?

Neural components of topographical representation.

The neural development and organization of letter recognition: evidence from functional neuroimaging, computational modeling, and behavioral studies.

The effects of practice on the functional anatomy of task performance.

The acquisition of skilled motor performance: fast and slow experience-driven changes in primary motor cortex.

Rapidly induced auditory plasticity: the ventriloquism aftereffect.

Components of verbal working memory: evidence from neuroimaging.

A neural system for human visual working memory.

Functional neuroimaging studies of encoding, priming, and explicit memory retrieval.

Anatomy of word and sentence meaning.

The role of left prefrontal cortex in language and memory.

Neuroimaging studies of word reading.

Cerebral organization for language in deaf and hearing subjects: biological constraints and effects of experience.

The environmental dependency of protein folding best explains prion and amyloid diseases.

Parallel processing in the nervous system: evidence from sensory maps.

Electric field-induced critical demixing in lipid bilayer membranes.

Analysis of the S3 and S3′ subsite specificities of feline immunodeficiency virus (FIV) protease: Development of a broad-based protease inhibitor efficacious against FIV, SIV, and HIV in vitro and ex vivo

Structure of the elongating ribosome: arrangement of the two tRNAs before and after translocation.

A translational repression assay procedure (TRAP) for RNA-protein interactions in vivo.

Identification and mutagenesis of a highly conserved domain in troponin T responsible for troponin I binding: Potential role for coiled coil interaction

Nlk is a murine protein kinase related to Erk/MAP kinases and localized in the nucleus

Studying the recruitment of Sp1 to the beta-globin promoter with an in vivo method: protein position identification with nuclease tail (PIN*POINT).

Mutational analysis of protein phosphatase 2C involved in abscisic acid signal transduction in higher plants

The 30-kDa C-terminal domain of the RecB protein is critical for the nuclease activity, but not the helicase activity, of the RecBCD enzyme from Escherichia coli.

A supersymmetric model for the evolution of the genetic code.

The von Hippel-Lindau tumor suppressor gene is required for cell cycle exit upon serum withdrawal.

In vitro assembly of a ribonucleoprotein particle corresponding to the platform domain of the 30S ribosomal subunit.

ATP-enhanced molecular chaperone functions of the small heat shock protein human alphaB crystallin.

Mammalian DNA topoisomerase IIIalpha is essential in early embryogenesis.

In vivo genomic footprinting analysis reveals that the complex Bradyrhizobium japonicum fixRnifA promoter region is differently occupied by two distinct RNA polymerase holoenzymes

Nativelike topology assembly of small proteins using predicted restraints in Monte Carlo folding simulations.

Opening-up of liposomal membranes by talin.

Spontaneous liposome formation induced by grafted poly(ethylene oxide) layers: theoretical prediction and experimental verification.

Increased expression of adenylylcyclase type VI proportionately increases beta-adrenergic receptor-stimulated production of cAMP in neonatal rat cardiac myocytes.

Defective stratum corneum and early neonatal death in mice lacking the gene for transglutaminase 1 (keratinocyte transglutaminase).

Tumorigenic conversion of immortal human keratinocytes through stromal cell activation.

Exit of major histocompatibility complex class II-invariant chain p35 complexes from the endoplasmic reticulum is modulated by phosphorylation.

De novo adipogenesis in mice at the site of injection of basement membrane and basic fibroblast growth factor.

Dendritic cell maturation and antigen presentation in the absence of invariant chain.

Coatomer, but not P200/myosin II, is required for the in vitro formation of trans-Golgi network-derived vesicles containing the envelope glycoprotein of vesicular stomatitis virus.

The rat gene homologous to the human gene 9-27 is involved in the development of the mammary gland.

The polyoma virus T antigen interferes with interferon-inducible gene expression.

Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1).

Shifts in the life history of parasitic wasps correlate with pronounced alterations in early development.

Identification of the Meg1/Grb10 imprinted gene on mouse proximal chromosome 11, a candidate for the Silver-Russell syndrome gene.

Rendering the inedible edible: circumvention of a millipede's chemical defense by a predaceous beetle larva.

X-ray-induced mutations in mouse embryonic stem cells.

Structure-function analysis of integrase interactor 1/hSNF5L1 reveals differential properties of two repeat motifs present in the highly conserved region

Tissues of MSH2-deficient mice demonstrate hypermutability on exposure to a DNA methylating agent.

p21WAF-1 reorganizes the nucleus in tumor suppression.

Targeted disruption of mouse centromere protein C gene leads to mitotic disarray and early embryo death.

Marrow stromal cells as a source of progenitor cells for nonhematopoietic tissues in transgenic mice with a phenotype of osteogenesis imperfecta.

Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport.

Kinetics of CD4+ T cell repopulation of lymphoid tissues after treatment of HIV-1 infection.

Interferon gamma-producing gammadelta T cell-dependent antibody isotype switching in the absence of germinal center formation during virus infection.

The antigen-binding characteristics of mAbs derived from in vivo priming of avian B cells.

HLA class I-specific inhibitory receptors in human T lymphocytes: interleukin 15-induced expression of CD94/NKG2A in superantigen- or alloantigen-activated CD8+ T cells.

Induction of antigen-specific T cell anergy: An early event in the course of tumor progression.

Human erythropoietin dimers with markedly enhanced in vivo activity.

Inhibition of HPV-16 E6/E7 immortalization of normal keratinocytes by hairpin ribozymes.

Hematopoietic stem cell deficiencies in mice lacking c-Mpl, the receptor for thrombopoietin.

Enhanced T cell engraftment after retroviral delivery of an antiviral gene in HIV-infected individuals.

Constitutive achlorhydria in mucolipidosis type IV.

Fas ligand gene transfer to the vessel wall inhibits neointima formation and overrides the adenovirus-mediated T cell response.

Basic fibroblast growth factor induces cell migration and proliferation after glia-specific gene transfer in mice.

PCR analysis of tissue samples from the 1979 Sverdlovsk anthrax victims: the presence of multiple Bacillus anthracis strains in different victims.

A family of chimeric erythrocyte binding proteins of malaria parasites.

The Arthromitus stage of Bacillus cereus: intestinal symbionts of animals.

Changes in cell-cycle kinetics during the development and evolution of primate neocortex.

Increased amyloidogenic secretion in cerebellar granule cells undergoing apoptosis.

Insulin-like growth factor I restores motor coordination in a rat model of cerebellar ataxia.

Fine structure of neural spiking and synchronization in the presence of conduction delays.

Improvement of neurological deficits in 6-hydroxydopamine-lesioned rats after transplantation with allogeneic simian virus 40 large tumor antigen gene-induced immortalized dopamine cells

A null mutation in the photoreceptor guanylate cyclase gene causes the retinal degeneration chicken phenotype.

Individual variation in neuron number predicts differences in the propensity for avian vocal imitation.

Readily releasable pool size changes associated with long term depression.

Identification of a neuregulin and protein-tyrosine phosphatase response element in the nicotinic acetylcholine receptor epsilon subunit gene: regulatory role of an Rts transcription factor.

Expression and regulation of GFRalpha3, a glial cell line-derived neurotrophic factor family receptor.

Aminoguanidine prevents age-related arterial stiffening and cardiac hypertrophy.

Activation of the atrial $K_{ACh}$ channel by the βγ subunits of G proteins or intracellular $Na^{+}$ ions depends on the presence of phosphatidylinositol phosphates

13C/31P NMR studies of glucose transport in human skeletal muscle.

The plastid ndh genes code for an NADH-specific dehydrogenase: isolation of a complex I analogue from pea thylakoid membranes.

Homology and functional similarity of an hrp-linked pathogenicity locus, dspEF, of Erwinia amylovora and the avirulence locus avrE of Pseudomonas syringae pathovar tomato.

mtDNA recombination in a natural population.

Grandmothering, menopause, and the evolution of human life histories.

Fifteen fatal fallacies of financial fundamentalism: a disquisition on demand-side economics.

Year: 1998 Volume: 95 Issue: 2

Year: 1998 Volume: 95 Issue: 1

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

Tumorigenic conversion of immortal human keratinocytes through stromal cell activation.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Skobe, M. Fusenig, N. E.
Description	Author Affiliation: Skobe M ( Division of Carcinogenesis and Differentiation, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.);
Abstract	The stromal microenvironment plays a crucial role in tumor development and progression. One of the most potent activators of stromal cells is the platelet-derived growth factor (PDGF). To investigate the role of PDGF in epithelial tumor development we stably transfected immortal nontumorigenic human keratinocytes with the PDGF-B cDNA. Transfected HaCaT cells overexpressed PDGF-B but remained negative for the PDGF receptors alpha and beta (mRNA). Thus, they did not exhibit autocrine growth stimulation in vitro, but proliferation of cocultured fibroblasts was enhanced and this effect was inhibited by a neutralizing antibody to PDGF-BB. After subcutaneous injection into nude mice the transfected cells maintained high PDGF expression and formed progressively enlarging, rapidly proliferating cysts, classified as benign tumors. During early tumor development (up to 2 months), PDGF-B transfectants induced marked mesenchymal cell proliferation and angiogenesis, yet this effect vanished at later stages (2-6 months) concomitantly with increased epithelial cell proliferation and enhanced tumor growth. These results demonstrate that an activated stromal environment can promote tumorigenic conversion of nontumorigenic keratinocytes by inducing sustained epithelial hyperproliferation. This effect is apparently caused by a dual action of PDGF-BB: (i) PDGF-BB can promote tumor growth by inducing angiogenesis and stroma formation, and (ii) PDGF-activated stromal cells maintain elevated keratinocyte proliferation via a paracrine mechanism. Thus, PDGF, a major factor activated in wound healing, may play an important role as an endogenous promoter in epithelial tumor formation.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	3
Volume Number	95
Language	English
Publisher	National Academy of Sciences
Publisher Date	1998-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cell Transformation, Neoplastic Keratinocytes Physiology Stromal Cells Animals Cell Division Drug Effects Cell Line Coculture Techniques Fibroblasts Cytology Mice Platelet-Derived Growth Factor Genetics Pharmacology Proto-Oncogene Proteins C-sis Skin Neoplasms Etiology Pathology Transfection Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in