NDLI: Aminoguanidine prevents age-related arterial stiffening and cardiac hypertrophy.

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Aminoguanidine prevents age-related arterial stiffening and cardiac hypertrophy.

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Aminoguanidine prevents age-related arterial stiffening and cardiac hypertrophy.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Duriez, M. Levy, B. I. Poitevin, P. Bruneval, P. Heudes, D. Tedgui, A. Corman, B.
Description	Author Affiliation: Corman B ( Service de Biologie Cellulaire, Commissariat à l'Energie Atomique, Centre d'Etudes de Saclay, Gif sur Yvette, 91191 Cedex, France.);
Abstract	Aging is associated with cardiac hypertrophy and arterial stiffening possibly associated with accumulation of advanced glycation end products (AGEs). We evaluated the effect of aminoguanidine, an inhibitor of AGE production, on end-stage alterations of renal and cardiovascular systems. Normotensive WAG/Rij rats were treated from 24 to 30 mo with aminoguanidine and compared with a control group. Aminoguanidine did not modify body and kidney weights but prevented the age-related cardiac hypertrophy (heart weight: 1276 +/- 28 mg and 1896 +/- 87 mg in 24- and 30-mo-old control animals and 1267 +/- 60 mg in 30-mo-old treated rats, P < 0.01). The increase in mesangial surface in aging rats was reduced by 30% by aminoguanidine. Collagen content of the arterial wall increased between 24 and 30 mo whereas elastin content, media thickness, and smooth muscle cell number remained unchanged. Aminoguanidine did not affect these parameters; however, the age-related increase in aortic impedance (12.4 +/- 1.4 and 18.2 +/- 1.9 10(3).dyne.sec.cm-5 in control 24- and 30-mo-old rats, P < 0.01) and the decrease in carotid distensibility (0.79 +/- 0.11 and 0.34 +/- 0. 07 mm Hg-1 in control 24- and 30-mo-old rats, P < 0.01) were prevented by aminoguanidine. The prevention of arterial stiffening and cardiac hypertrophy in the absence of changes in collagen and elastin content suggests that the effect of aminoguanidine is related to a decrease in the AGE-induced cross-linking of the extracellular matrix.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	3
Volume Number	95
Language	English
Publisher	National Academy of Sciences
Publisher Date	1998-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Aging Drug Effects Aorta Cardiomegaly Metabolism Enzyme Inhibitors Pharmacology Guanidines Pathology Animals Blood Pressure Cardiac Output Carotid Arteries Elasticity Extracellular Matrix Proteins Glycosylation End Products, Advanced Kidney Longevity Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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