NDLI: A substrate of the centisome 63 type III protein secretion system of Salmonella typhimurium is encoded by a cryptic bacteriophage.

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Plant genomics and our food supply: an introduction.

Comparative genetics in the grasses.

Down-regulation of RFL, the FLO/LFY homolog of rice, accompanied with panicle branch initiation.

Toward a plant genomics initiative: thoughts on the value of cross-species and cross-genera comparisons in the grasses.

Plant genomics: more than food for thought.

Assisting developing countries toward food self-reliance.

Toward a successful multinational crop plant genome initiative.

Quantitative trait loci and metabolic pathways.

Genome projects and gene pools: new germplasm for plant breeding?

Relationships of cereal crops and other grasses.

Plant genome values: how much do we know?

Importance of anchor genomes for any plant genome project.

Functional genomics: probing plant gene function and expression with transposons.

The rice genome project in Japan.

Potentials of the National Corn Genome Initiative.

Targeted disruption of the HFE gene.

Enzyme engineering reaches the boiling point.

A base called J.

Optimal modulation of a Brownian ratchet and enhanced sensitivity to a weak external force.

Multiple evolutionary origins of the fungus causing Panama disease of banana: concordant evidence from nuclear and mitochondrial gene genealogies.

Antagonism of glucocorticoid receptor transcriptional activation by the c-Jun N-terminal kinase.

Engineering an enzyme to resist boiling.

CREB-binding protein cooperates with transcription factor GATA-1 and is required for erythroid differentiation.

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Inhibition of translation and bacterial growth by peptide nucleic acid targeted to ribosomal RNA.

Domain requirements for the Dock adapter protein in growth- cone signaling

Retrotransposon R1Bm endonuclease cleaves the target sequence.

A cysteine-rich domain of the 'mannose' receptor mediates GalNAc-4-SO4 binding.

Codominant interference, antieffectors, and multitarget drugs.

A family of transketolases that directs isoprenoid biosynthesis via a mevalonate-independent pathway.

Cloning and characterization of a gene from Escherichia coli encoding a transketolase-like enzyme that catalyzes the synthesis of D-1-deoxyxylulose 5-phosphate, a common precursor for isoprenoid, thiamin, and pyridoxol biosynthesis.

A method for assaying intestinal brush-border sucrase in an intact intestinal preparation.

Evolutionary matches of enzyme and transporter capacities to dietary substrate loads in the intestinal brush border.

CREB-binding protein in androgen receptor-mediated signaling.

Peroxisomal D-hydroxyacyl-CoA dehydrogenase deficiency: resolution of the enzyme defect and its molecular basis in bifunctional protein deficiency.

Integration of the Tetrahymena group I intron into bacterial rRNA by reverse splicing in vivo.

Reversible dissociation of coatomer: functional characterization of a beta/delta-coat protein subcomplex.

A cofactor, TIP30, specifically enhances HIV-1 Tat-activated transcription.

Sequence-specific ligation of DNA using RecA protein.

In vitro selection of a purine nucleotide-specific hammerheadlike ribozyme.

SR proteins are sufficient for exon bridging across an intron.

Aggregation of the human high affinity immunoglobulin G receptor (FcgammaRI) activates both tyrosine kinase and G protein-coupled phosphoinositide 3-kinase isoforms.

Accelerated reaction of nitric oxide with $O_{2}$ within the hydrophobic interior of biological membranes

Isotope exchange studies on the Escherichia coli selenophosphate synthetase mechanism.

Changes in solvation during DNA binding and cleavage are critical to altered specificity of the EcoRI endonuclease.

A dynamic model for PC4 coactivator function in RNA polymerase II transcription

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Evidence for distinct mechanisms of transition state stabilization of GTPases by fluoride.

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Skeletal overgrowth in transgenic mice that overexpress brain natriuretic peptide.

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A substrate of the centisome 63 type III protein secretion system of Salmonella typhimurium is encoded by a cryptic bacteriophage.

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Comparison of the auditory systems of heterosexuals and homosexuals: click-evoked otoacoustic emissions.

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A substrate of the centisome 63 type III protein secretion system of Salmonella typhimurium is encoded by a cryptic bacteriophage.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hardt, W. D. Urlaub, H. Galán, J. E.
Description	Author Affiliation: Hardt WD ( Department of Molecular Genetics and Microbiology, State University of New York at Stony Brook, Stony Brook, NY 11794-5222, USA.);
Abstract	Salmonella enterica has evolved a type III protein secretion system that allows these enteropathogens to translocate effector molecules directly into the host cell cytoplasm. These effectors mediate a variety of responses, including cytoskeletal rearrangements, cytokine production, and in certain cells, the induction of apoptosis. We report here the characterization of a substrate of this secretion system in S. enterica serovar typhimurium (Salmonella typhimurium) that is homologous to the SopE protein of Salmonella dublin implicated in bacterial entry into cultured epithelial cells. The sopE locus is located within a cluster of genes that encode tail and tail fiber proteins of a cryptic P2-like prophage, outside of the centisome 63 pathogenicity island that encodes the invasion-associated type III secretion system. Southern hybridization analysis revealed that sopE is present in only a subset of S. enterica serovars and that the flanking bacteriophage genes are also highly polymorphic. Encoding effector proteins that are delivered through type III secretion systems in highly mobile genetic elements may allow pathogens to adapt rapidly by facilitating the assembly of an appropriate set of effector proteins required for successful replication in a new environment.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	5
Volume Number	95
Language	English
Publisher	National Academy of Sciences
Publisher Date	1998-04-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Bacterial Proteins Biosynthesis Salmonella Phages Physiology Salmonella Typhimurium Genetics Virology Salmonella Viral Proteins Amino Acid Sequence Animals Chemistry Genes, Viral Genotype Mice Molecular Sequence Data Multigene Family Salmonella Infections, Animal Physiopathology Pathogenicity Sequence Alignment Substrate Specificity Virulence Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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