NDLI: Induction of transporter associated with antigen processing by interferon gamma confers endothelial cell cytoprotection against natural killer-mediated lysis.

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Plant genomics and our food supply: an introduction.

Comparative genetics in the grasses.

Down-regulation of RFL, the FLO/LFY homolog of rice, accompanied with panicle branch initiation.

Toward a plant genomics initiative: thoughts on the value of cross-species and cross-genera comparisons in the grasses.

Plant genomics: more than food for thought.

Assisting developing countries toward food self-reliance.

Toward a successful multinational crop plant genome initiative.

Quantitative trait loci and metabolic pathways.

Genome projects and gene pools: new germplasm for plant breeding?

Relationships of cereal crops and other grasses.

Plant genome values: how much do we know?

Importance of anchor genomes for any plant genome project.

Functional genomics: probing plant gene function and expression with transposons.

The rice genome project in Japan.

Potentials of the National Corn Genome Initiative.

Targeted disruption of the HFE gene.

Enzyme engineering reaches the boiling point.

A base called J.

Optimal modulation of a Brownian ratchet and enhanced sensitivity to a weak external force.

Multiple evolutionary origins of the fungus causing Panama disease of banana: concordant evidence from nuclear and mitochondrial gene genealogies.

Antagonism of glucocorticoid receptor transcriptional activation by the c-Jun N-terminal kinase.

Engineering an enzyme to resist boiling.

CREB-binding protein cooperates with transcription factor GATA-1 and is required for erythroid differentiation.

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Inhibition of translation and bacterial growth by peptide nucleic acid targeted to ribosomal RNA.

Domain requirements for the Dock adapter protein in growth- cone signaling

Retrotransposon R1Bm endonuclease cleaves the target sequence.

A cysteine-rich domain of the 'mannose' receptor mediates GalNAc-4-SO4 binding.

Codominant interference, antieffectors, and multitarget drugs.

A family of transketolases that directs isoprenoid biosynthesis via a mevalonate-independent pathway.

Cloning and characterization of a gene from Escherichia coli encoding a transketolase-like enzyme that catalyzes the synthesis of D-1-deoxyxylulose 5-phosphate, a common precursor for isoprenoid, thiamin, and pyridoxol biosynthesis.

A method for assaying intestinal brush-border sucrase in an intact intestinal preparation.

Evolutionary matches of enzyme and transporter capacities to dietary substrate loads in the intestinal brush border.

CREB-binding protein in androgen receptor-mediated signaling.

Peroxisomal D-hydroxyacyl-CoA dehydrogenase deficiency: resolution of the enzyme defect and its molecular basis in bifunctional protein deficiency.

Integration of the Tetrahymena group I intron into bacterial rRNA by reverse splicing in vivo.

Reversible dissociation of coatomer: functional characterization of a beta/delta-coat protein subcomplex.

A cofactor, TIP30, specifically enhances HIV-1 Tat-activated transcription.

Sequence-specific ligation of DNA using RecA protein.

In vitro selection of a purine nucleotide-specific hammerheadlike ribozyme.

SR proteins are sufficient for exon bridging across an intron.

Aggregation of the human high affinity immunoglobulin G receptor (FcgammaRI) activates both tyrosine kinase and G protein-coupled phosphoinositide 3-kinase isoforms.

Accelerated reaction of nitric oxide with $O_{2}$ within the hydrophobic interior of biological membranes

Isotope exchange studies on the Escherichia coli selenophosphate synthetase mechanism.

Changes in solvation during DNA binding and cleavage are critical to altered specificity of the EcoRI endonuclease.

A dynamic model for PC4 coactivator function in RNA polymerase II transcription

Daidzin and its antidipsotropic analogs inhibit serotonin and dopamine metabolism in isolated mitochondria.

Amine binding and oxidation at the catalytic site for photosynthetic water oxidation.

Evidence for distinct mechanisms of transition state stabilization of GTPases by fluoride.

Germacrene C synthase from Lycopersicon esculentum cv. VFNT cherry tomato: cDNA isolation, characterization, and bacterial expression of the multiple product sesquiterpene cyclase.

A serine cluster prevents recycling of the V2 vasopressin receptor.

Brome mosaic virus RNA replication protein 1a dramatically increases in vivo stability but not translation of viral genomic RNA3.

Cleaving DNA with DNA.

A poly(A) binding protein functions in the chloroplast as a message-specific translation factor.

Junction ribonuclease: an activity in Okazaki fragment processing.

Oxa1p, an essential component of the N-tail protein export machinery in mitochondria.

High-throughput genetic analysis using microfabricated 96-sample capillary array electrophoresis microplates.

Structure comparison of human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein P14a indicates a functional link between the human immune system and a plant defense system.

Protein hydration in solution: Experimental observation by x-ray and neutron scattering

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Vesicles on strings: morphological evidence for processive transport within the Golgi stack.

Stabilization and activation of p53 are regulated independently by different phosphorylation events.

Human papillomavirus type 16 E6 and E7 oncogenes abrogate radiation-induced DNA damage responses in vivo through p53-dependent and p53-independent pathways.

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BRCA1 regulates p53-dependent gene expression.

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Presence and phosphorylation of transcription factors in developing dendrites.

Hsp70 accumulation in chondrocytic cells exposed to high continuous hydrostatic pressure coincides with mRNA stabilization rather than transcriptional activation

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RNA-binding protein TIAR is essential for primordial germ cell development.

Skeletal overgrowth in transgenic mice that overexpress brain natriuretic peptide.

Isolation of a Drosophila homolog of the vertebrate homeobox gene Rx and its possible role in brain and eye development.

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Chromosomal drive and the evolution of meiotic nondisjunction and trisomy in humans.

beta-D-glucosyl-hydroxymethyluracil is a conserved DNA modification in kinetoplastid protozoans and is abundant in their telomeres.

Aging, mating, and the evolution of mtDNA heteroplasmy in Drosophila melanogaster

Evolutionary analyses of the 12-kDa acidic ribosomal P-proteins reveal a distinct protein of higher plant ribosomes

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SHOT, a SHOX-related homeobox gene, is implicated in craniofacial, brain, heart, and limb development.

Targeted deletion of Smad4 shows it is required for transforming growth factor beta and activin signaling in colorectal cancer cells.

An additional role for the F-box motif: Gene regulation within the Neurospora crassa sulfur control network

Both allelic variation and expression of nuclear and cytoplasmic transcripts of Hsr-omega are closely associated with thermal phenotype in Drosophila.

Cdkn2a, the cyclin-dependent kinase inhibitor encoding p16INK4a and p19ARF, is a candidate for the plasmacytoma susceptibility locus, Pctr1.

Induction of transporter associated with antigen processing by interferon gamma confers endothelial cell cytoprotection against natural killer-mediated lysis.

Prevention of Th2-mediated murine allergic airways disease by soluble antigen administration in the neonate.

The paired Ig-like receptor PIR-B is an inhibitory receptor that recruits the protein-tyrosine phosphatase SHP-1.

Human T cell lymphotropic virus type I Tax protein trans-activates interleukin 15 gene transcription through an NF-kappaB site.

CD81 on B cells promotes interleukin 4 secretion and antibody production during T helper type 2 immune responses.

Frequent occurrence of deletions and duplications during somatic hypermutation: implications for oncogene translocations and heavy chain disease.

The role of inducible nitric oxide synthase in the host response to Coxsackievirus myocarditis

Gene therapy with a single chain interleukin 12 fusion protein induces T cell-dependent protective immunity in a syngeneic model of murine neuroblastoma.

Immunization against rabies with plant-derived antigen.

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Induction of transporter associated with antigen processing by interferon gamma confers endothelial cell cytoprotection against natural killer-mediated lysis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Bender, J. R. Lee, J. O'donnell, L. Ayalon, O. Cresswell, P. Pardi, R. Hughes, E. A.
Description	Author Affiliation: Ayalon O ( Division of Cardiovascular Medicine and Molecular Cardiobiology, Boyer Center for Molecular Medicine, The Raymond and Beverly Sackler Foundation Cardiobiology Laboratory, Yale University School of Medicine, New Haven, CT 06536-0812, USA.);
Abstract	T lymphocytes react minimally with nonactivated endothelial cells (ECs). However, natural killer (NK) lymphocyte interactions with resting ECs are rapid, avid, and result in endothelial activation and/or cytotoxicity. The molecular basis for these interactions and EC sensitivity to NK-mediated lysis is unclear. To address the EC-specific nature of NK sensitivity, we used syngeneic human umbilical vein ECs, dermal microvascular ECs, dermal fibroblasts, and B lymphoblastoid cell lines in calcein-AM retention NK assays with allogeneic NK effector cells and found the EC lines consistently more NK-sensitive. Because NK inhibitory receptors are engaged by membrane major histocompatibility complex (MHC) I molecules and MHC I-deficient targets are NK-sensitive, we investigated the quantitative levels of membrane MHC I on the panel of syngeneic lines. Highly sensitive ECs expressed similar (or higher) levels of membrane MHC I than their syngeneic NK-resistant counterparts. Pretreatment of ECs with gamma interferon (IFN-gamma) conferred protection against NK-mediated lysis, with much more rapid kinetics (2-6 hr) than those required for membrane MHC I hyperinduction (>8 hr). These kinetics are consistent with induction of transporter associated with antigen processing (TAP) expression and function. As opposed to NK-resistant cell lines, TAP-1 was undetectable in resting ECs. Recombinant expression of the TAP inactivator ICP47 by adenoviral-mediated transduction was used to selectively inhibit IFN-gamma-mediated EC TAP function. ICP47 expression abrogated EC cytoprotection conferred by IFN-gamma. We demonstrate a relationship between both basal and induced TAP-1 expression/function and EC sensitivity to NK-mediated cytotoxicity. We discuss the influence of an induced MHC I-associated peptide repertoire on vascular vulnerability to cytotoxic lymphocytes.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	5
Volume Number	95
Language	English
Publisher	National Academy of Sciences
Publisher Date	1998-04-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Carrier Proteins Biosynthesis Cytotoxicity, Immunologic Endothelium, Vascular Immunology Histocompatibility Antigens Class I Physiology Interferon-gamma Pharmacology Killer Cells, Natural B-Lymphocytes Cell Membrane Cells, Cultured Drug Effects Kinetics Recombinant Proteins Skin Transfection Umbilical Veins Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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