NDLI: HFE gene knockout produces mouse model of hereditary hemochromatosis.

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HFE gene knockout produces mouse model of hereditary hemochromatosis.

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HFE gene knockout produces mouse model of hereditary hemochromatosis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Waheed, A. Jiang, J. Brunt, E. M. Schatzman, R. C. O'neill, R. Britton, R. S. Fleming, R. E. Prass, C. E. Parkkila, S. Bacon, B. R. Sly, W. S. Zhou, X. Y. Fei, Y. Tomatsu, S. Ruddy, D. A.
Description	Author Affiliation: Zhou XY ( Edward A. Doisy Department of Biochemistry and Molecular Biology, St. Louis University School of Medicine, 1402 South Grand Boulevard, St. Louis, MO 63104, USA.);
Abstract	Hereditary hemochromatosis (HH) is a common autosomal recessive disease characterized by increased iron absorption and progressive iron storage that results in damage to major organs in the body. Recently, a candidate gene for HH called HFE encoding a major histocompatibility complex class I-like protein was identified by positional cloning. Nearly 90% of Caucasian HH patients have been found to be homozygous for the same mutation (C282Y) in the HFE gene. To test the hypothesis that the HFE gene is involved in regulation of iron homeostasis, we studied the effects of a targeted disruption of the murine homologue of the HFE gene. The HFE-deficient mice showed profound differences in parameters of iron homeostasis. Even on a standard diet, by 10 weeks of age, fasting transferrin saturation was significantly elevated compared with normal littermates (96 +/- 5% vs. 77 +/- 3%, P < 0.007), and hepatic iron concentration was 8-fold higher than that of wild-type littermates (2,071 +/- 450 vs. 255 +/- 23 microg/g dry wt, P < 0.002). Stainable hepatic iron in the HFE mutant mice was predominantly in hepatocytes in a periportal distribution. Iron concentrations in spleen, heart, and kidney were not significantly different. Erythroid parameters were normal, indicating that the anemia did not contribute to the increased iron storage. This study shows that the HFE protein is involved in the regulation of iron homeostasis and that mutations in this gene are responsible for HH. The knockout mouse model of HH will facilitate investigation into the pathogenesis of increased iron accumulation in HH and provide opportunities to evaluate therapeutic strategies for prevention or correction of iron overload.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	5
Volume Number	95
Language	English
Publisher	National Academy of Sciences
Publisher Date	1998-04-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	HLA Antigens Genetics Physiology Hemochromatosis Immunology Histocompatibility Antigens Class I Major Histocompatibility Complex Membrane Proteins Animals Genes, Recessive Blood Metabolism Kidney Liver Pathology Mice Mice, Inbred Strains Mice, Knockout Spleen Transferrin Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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