NDLI: Ectopic induction of Clb2 in early G1 phase is sufficient to block prereplicative complex formation in Saccharomyces cerevisiae.

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Plant genomics and our food supply: an introduction.

Comparative genetics in the grasses.

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Plant genomics: more than food for thought.

Assisting developing countries toward food self-reliance.

Toward a successful multinational crop plant genome initiative.

Quantitative trait loci and metabolic pathways.

Genome projects and gene pools: new germplasm for plant breeding?

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Plant genome values: how much do we know?

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Functional genomics: probing plant gene function and expression with transposons.

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Ectopic induction of Clb2 in early G1 phase is sufficient to block prereplicative complex formation in Saccharomyces cerevisiae.

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Ectopic induction of Clb2 in early G1 phase is sufficient to block prereplicative complex formation in Saccharomyces cerevisiae.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Detweiler, C. S. Li, J. J.
Description	Author Affiliation: Detweiler CS ( Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143-0448, USA.);
Abstract	Eukaryotic cells ensure the stable propagation of their genome by coupling each round of DNA replication (S phase) to passage through mitosis (M phase). This control is exerted at the initiation of replication, which occurs at multiple origins throughout the genome. Once an origin has initiated, reinitiation is blocked until the completion of mitosis, ensuring that DNA is replicated at most once per cell cycle. Recent studies in several organisms have suggested a model in which S- and M-phase promoting cyclin-dependent kinases prevent reinitiation by blocking the repetition of an early step in the initiation reaction. In budding yeast, this regulation is thought to involve inhibition of prereplicative complex (pre-RC) formation at origins by S and M phase-promoting Clb kinases. To date, however, there has been no direct demonstration that these kinases can perform such an important function. In this report we provide such a confirmation by showing that ectopic induction in G1 phase of a mitotic Clb, Clb2, is sufficient to inhibit DNA replication and does so by preventing pre-RC formation. This inhibition requires that Clb2 be induced before Cdc6, an initiation protein required for pre-RC formation; once pre-RCs have formed, Clb2 can no longer inhibit initiation. These results support the notion that during the normal cell cycle reassembly of the pre-RC, and hence reinitiation at an origin, is directly inhibited by S and M phase-promoting cyclin-dependent kinases.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	5
Volume Number	95
Language	English
Publisher	National Academy of Sciences
Publisher Date	1998-04-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cell Cycle Genetics Cyclin B Cyclins Biosynthesis DNA Replication Saccharomyces Cerevisiae Proteins Saccharomyces Cerevisiae Fungal Proteins G1 Phase Models, Biological Cytology Growth & Development Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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