NDLI: CD81 on B cells promotes interleukin 4 secretion and antibody production during T helper type 2 immune responses.

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Plant genomics and our food supply: an introduction.

Comparative genetics in the grasses.

Down-regulation of RFL, the FLO/LFY homolog of rice, accompanied with panicle branch initiation.

Toward a plant genomics initiative: thoughts on the value of cross-species and cross-genera comparisons in the grasses.

Plant genomics: more than food for thought.

Assisting developing countries toward food self-reliance.

Toward a successful multinational crop plant genome initiative.

Quantitative trait loci and metabolic pathways.

Genome projects and gene pools: new germplasm for plant breeding?

Relationships of cereal crops and other grasses.

Plant genome values: how much do we know?

Importance of anchor genomes for any plant genome project.

Functional genomics: probing plant gene function and expression with transposons.

The rice genome project in Japan.

Potentials of the National Corn Genome Initiative.

Targeted disruption of the HFE gene.

Enzyme engineering reaches the boiling point.

A base called J.

Optimal modulation of a Brownian ratchet and enhanced sensitivity to a weak external force.

Multiple evolutionary origins of the fungus causing Panama disease of banana: concordant evidence from nuclear and mitochondrial gene genealogies.

Antagonism of glucocorticoid receptor transcriptional activation by the c-Jun N-terminal kinase.

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CREB-binding protein cooperates with transcription factor GATA-1 and is required for erythroid differentiation.

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Domain requirements for the Dock adapter protein in growth- cone signaling

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A family of transketolases that directs isoprenoid biosynthesis via a mevalonate-independent pathway.

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A method for assaying intestinal brush-border sucrase in an intact intestinal preparation.

Evolutionary matches of enzyme and transporter capacities to dietary substrate loads in the intestinal brush border.

CREB-binding protein in androgen receptor-mediated signaling.

Peroxisomal D-hydroxyacyl-CoA dehydrogenase deficiency: resolution of the enzyme defect and its molecular basis in bifunctional protein deficiency.

Integration of the Tetrahymena group I intron into bacterial rRNA by reverse splicing in vivo.

Reversible dissociation of coatomer: functional characterization of a beta/delta-coat protein subcomplex.

A cofactor, TIP30, specifically enhances HIV-1 Tat-activated transcription.

Sequence-specific ligation of DNA using RecA protein.

In vitro selection of a purine nucleotide-specific hammerheadlike ribozyme.

SR proteins are sufficient for exon bridging across an intron.

Aggregation of the human high affinity immunoglobulin G receptor (FcgammaRI) activates both tyrosine kinase and G protein-coupled phosphoinositide 3-kinase isoforms.

Accelerated reaction of nitric oxide with $O_{2}$ within the hydrophobic interior of biological membranes

Isotope exchange studies on the Escherichia coli selenophosphate synthetase mechanism.

Changes in solvation during DNA binding and cleavage are critical to altered specificity of the EcoRI endonuclease.

A dynamic model for PC4 coactivator function in RNA polymerase II transcription

Daidzin and its antidipsotropic analogs inhibit serotonin and dopamine metabolism in isolated mitochondria.

Amine binding and oxidation at the catalytic site for photosynthetic water oxidation.

Evidence for distinct mechanisms of transition state stabilization of GTPases by fluoride.

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Cleaving DNA with DNA.

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Junction ribonuclease: an activity in Okazaki fragment processing.

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BRCA1 regulates p53-dependent gene expression.

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RNA-binding protein TIAR is essential for primordial germ cell development.

Skeletal overgrowth in transgenic mice that overexpress brain natriuretic peptide.

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Protein kinase A directly regulates the activity and proteolysis of cubitus interruptus.

Modification of expression and cis-regulation of Hoxc8 in the evolution of diverged axial morphology.

Chromosomal drive and the evolution of meiotic nondisjunction and trisomy in humans.

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Aging, mating, and the evolution of mtDNA heteroplasmy in Drosophila melanogaster

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The partial tandem duplication of ALL1 (MLL) is consistently generated by Alu-mediated homologous recombination in acute myeloid leukemia.

The Ig mutator is dependent on the presence, position, and orientation of the large intron enhancer.

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Targeted deletion of Smad4 shows it is required for transforming growth factor beta and activin signaling in colorectal cancer cells.

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Induction of transporter associated with antigen processing by interferon gamma confers endothelial cell cytoprotection against natural killer-mediated lysis.

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Human T cell lymphotropic virus type I Tax protein trans-activates interleukin 15 gene transcription through an NF-kappaB site.

CD81 on B cells promotes interleukin 4 secretion and antibody production during T helper type 2 immune responses.

Frequent occurrence of deletions and duplications during somatic hypermutation: implications for oncogene translocations and heavy chain disease.

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Immunization against rabies with plant-derived antigen.

Two distinct pathways of positive selection for thymocytes.

HFE gene knockout produces mouse model of hereditary hemochromatosis.

Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes.

Mice with type 2 and 3 Gaucher disease point mutations generated by a single insertion mutagenesis procedure.

A simplified system for generating recombinant adenoviruses.

Modulation of GTPase activity of G proteins by fluid shear stress and phospholipid composition.

Vaccination with an attenuated Creutzfeldt-Jakob disease strain prevents expression of a virulent agent.

Ectopic expression of N-acetylglucosaminyltransferase III in transgenic hepatocytes disrupts apolipoprotein B secretion and induces aberrant cellular morphology with lipid storage.

Model studies directed toward the application of boron neutron capture therapy to rheumatoid arthritis: boron delivery by liposomes in rat collagen-induced arthritis.

Identification of a substrate-targeting domain in cyclin E necessary for phosphorylation of the retinoblastoma protein.

Synchronicity of frequently sampled, 24-h concentrations of circulating leptin, luteinizing hormone, and estradiol in healthy women.

Natriuretic peptide receptor 1 expression influences blood pressures of mice in a dose-dependent manner

Angiotensin-converting enzyme and male fertility.

Acceleration of amyloid protein A amyloidosis by amyloid-like synthetic fibrils.

Identification in a pseudoknot of a U.G motif essential for the regulation of the expression of ribosomal protein S15.

The chemotaxis system, but not chemotaxis, is essential for swarming motility in Escherichia coli.

A substrate of the centisome 63 type III protein secretion system of Salmonella typhimurium is encoded by a cryptic bacteriophage.

Receptor-triggered membrane association of a model retroviral glycoprotein.

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Neural cell adhesion molecule (N-CAM) domains and intracellular signaling pathways involved in the inhibition of astrocyte proliferation.

Allosteric modulation of AMPA-type glutamate receptors increases activity of the promoter for the neural cell adhesion molecule, N-CAM.

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Overrepresentation of horizontal and vertical orientation preferences in developing ferret area 17.

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Unequal representation of cardinal and oblique contours in ferret visual cortex.

Effects of feline immunodeficiency virus on astrocyte glutamate uptake: implications for lentivirus-induced central nervous system diseases.

Hypoalgesia in mice with a targeted deletion of the tachykinin 1 gene.

Functional disruption in the organization of the brain for reading in dyslexia.

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Expression of Q227L-galphas in MCF-7 human breast cancer cells inhibits tumorigenesis.

Point mutations in segment I-S6 render voltage-gated $Na^{+}channels$ resistant to batrachotoxin

Peroxynitrite decomposition catalysts: therapeutics for peroxynitrite-mediated pathology.

Prevention of renovascular and cardiac pathophysiological changes in hypertension by angiotensin II type 1 receptor antisense gene therapy

New findings of the correlation between acupoints and corresponding brain cortices using functional MRI.

Chloride channel and chloride conductance regulator domains of CFTR, the cystic fibrosis transmembrane conductance regulator.

Fatty acids suppress voltage-gated $Na^{+}$ currents in HEK293t cells transfected with the α-subunit of the human cardiac $Na^{+}$ channel

Enhancement of blue-light sensitivity of Arabidopsis seedlings by a blue light receptor cryptochrome 2.

Response regulators implicated in His-to-Asp phosphotransfer signaling in Arabidopsis.

Abscisic acid signal transduction in the barley aleurone is mediated by phospholipase D activity.

Neural correlates of the episodic encoding of pictures and words.

Comparison of the auditory systems of heterosexuals and homosexuals: click-evoked otoacoustic emissions.

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CD81 on B cells promotes interleukin 4 secretion and antibody production during T helper type 2 immune responses.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Do, M. S. Maecker, H. T. Levy, S.
Description	Author Affiliation: Maecker HT ( Department of Medicine/Oncology, Stanford University Medical Center, Stanford, CA 94305, USA. hmaecker@cmgm.stanford.edu);
Abstract	Mice lacking CD81 (TAPA-1), a widely expressed tetraspanin molecule, have impaired antibody responses to protein antigens. This defect is specific to antigens that preferentially stimulate a T helper 2 response (ovalbumin or keyhole limpet hemocyanin in alum) and is only seen with T cell-dependent antigens. Absence of CD81 on B cells is sufficient to cause the defect. Also, antigen-specific interleukin (IL) 4 production is greatly reduced in the spleen and lymph nodes of CD81-null mice compared with heterozygous littermates. Thus, expression of CD81 on B cells is critical for inducing optimal IL-4 and antibody production during T helper 2 responses. These findings suggest that CD81 may interact with a ligand on T cells to signal IL-4 production. By using a soluble form of CD81 as a probe, a putative ligand for CD81 was identified on a subset of B and T cells. Two possible models for the interaction of CD81 on B cells with a potential ligand on either B or T cells are proposed.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	5
Volume Number	95
Language	English
Publisher	National Academy of Sciences
Publisher Date	1998-04-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antigens, CD Genetics Physiology B-Lymphocytes Immunology Interleukin-4 Biosynthesis Th2 Cells Animals Antibody Formation Antigens, CD81 Chimera Enzyme-Linked Immunosorbent Assay Hemocyanin Heterozygote Immunoglobulin G Blood Interferon-gamma Secretion Lymph Nodes Membrane Proteins Deficiency Mice Mice, Knockout Models, Immunological Ovalbumin Spleen Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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