NDLI: Induction of an acetaminophen-sensitive cyclooxygenase with reduced sensitivity to nonsteroid antiinflammatory drugs.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1999 Volume: 96 Issue: 26

Year: 1999 Volume: 96 Issue: 25

Year: 1999 Volume: 96 Issue: 24

Year: 1999 Volume: 96 Issue: 23

Year: 1999 Volume: 96 Issue: 22

Year: 1999 Volume: 96 Issue: 21

Year: 1999 Volume: 96 Issue: 20

Year: 1999 Volume: 96 Issue: 19

Year: 1999 Volume: 96 Issue: 18

Year: 1999 Volume: 96 Issue: 17

Year: 1999 Volume: 96 Issue: 16

Year: 1999 Volume: 96 Issue: 15

Year: 1999 Volume: 96 Issue: 14

Year: 1999 Volume: 96 Issue: 13

Year: 1999 Volume: 96 Issue: 12

Year: 1999 Volume: 96 Issue: 11

Year: 1999 Volume: 96 Issue: 10

Year: 1999 Volume: 96 Issue: 9

Year: 1999 Volume: 96 Issue: 8

Year: 1999 Volume: 96 Issue: 7

Year: 1999 Volume: 96 Issue: 6

Fit for life in the immune system? Surrogate L chain tests H chains that test L chains.

A notable cleavage: winding up with beta-amyloid.

Heart or hand? Unmasking the basis for specific Holt-Oram phenotypes.

More surprises from Kinetoplastida.

More on the X files.

Attention and primary visual cortex.

The dynamic dialogue between cells and matrices: implications of fibronectin's elasticity.

A hierarchical approach to protein molecular evolution.

The topomer-sampling model of protein folding.

Femtosecond dynamics of dative bonding: Concepts of reversible and dissociative electron transfer reactions

Protein folding at the air-water interface studied with x-ray reflectivity.

On the behavior of hyperbolic neutral points in two-dimensional ideal magnetohydrodynamics.

Site-specific integration mediated by a hybrid adenovirus/adeno-associated virus vector.

Structural characteristics of supramolecular assemblies formed by guanidinium-cholesterol reagents for gene transfection.

Modulation of CREB binding protein function by the promyelocytic (PML) oncoprotein suggests a role for nuclear bodies in hormone signaling.

Human T-cell leukemia retrovirus-Tax protein is a repressor of nuclear receptor signaling.

Unique forms of human and mouse nuclear receptor corepressor SMRT.

Troponin I is present in human cartilage and inhibits angiogenesis.

Serine-arginine (SR)-rich splicing factors have an exon-independent function in pre-mRNA splicing.

The fission yeast homologue of Orc4p binds to replication origin DNA via multiple AT-hooks.

Core structure of the envelope glycoprotein GP2 from Ebola virus at 1.9-A resolution.

Transcriptional activation by artificial recruitment in yeast is influenced by promoter architecture and downstream sequences.

Transcriptional activation by artificial recruitment in mammalian cells.

Lysozyme and RNases as anti-HIV components in beta-core preparations of human chorionic gonadotropin.

GroES in the asymmetric GroEL14-GroES7 complex exchanges via an associative mechanism.

Yeast flavin-containing monooxygenase generates oxidizing equivalents that control protein folding in the endoplasmic reticulum.

Identification of a transcription factor, encoded by two vaccinia virus early genes, that regulates the intermediate stage of viral gene expression.

A strategy for rapid sequencing of heparan sulfate and heparin saccharides.

HIV-1 Gag shares a signature motif with annexin (Anx7), which is required for virus replication.

Characterization of Sam68-like mammalian proteins SLM-1 and SLM-2: SLM-1 is a Src substrate during mitosis

Iron availability dramatically alters the distribution of ferritin subunit messages in Drosophila melanogaster.

Tissue-specific processing of cocaine- and amphetamine-regulated transcript peptides in the rat.

Specific interaction of Tat with the human but not rodent P-TEFb complex mediates the species-specific Tat activation of HIV-1 transcription.

In vitro suicide inhibition of self-splicing of a group I intron from Pneumocystis carinii by an N3' --> P5' phosphoramidate hexanucleotide.

Mutation analysis of the Pip interaction domain reveals critical residues for protein-protein interactions.

Phosphorylating DNA with DNA.

Structural basis for the inhibitory effect of brefeldin A on guanine nucleotide-exchange proteins for ADP-ribosylation factors.

Toward controlling gene expression at will: selection and design of zinc finger domains recognizing each of the 5'-GNN-3' DNA target sequences.

An activation-specific role for transcription factor TFIIB in vivo

Molecular model of muscle contraction.

Interpretation of the spatial charge displacements in bacteriorhodopsin in terms of structural changes during the photocycle.

Multiple pathways on a protein-folding energy landscape: kinetic evidence.

Estradiol induces the calcium-dependent translocation of endothelial nitric oxide synthase

The Opitz syndrome gene product, MID1, associates with microtubules.

DNA replication in vertebrates requires a homolog of the Cdc7 protein kinase.

Syndecan-4 signals cooperatively with integrins in a Rho-dependent manner in the assembly of focal adhesions and actin stress fibers.

Angiostatin binds ATP synthase on the surface of human endothelial cells.

Cyclin-dependent kinase control of centrosome duplication.

Histidine-tagged wild-type yeast actin: its properties and use in an approach for obtaining yeast actin mutants.

A mutant deubiquitinating enzyme (Ubp-M) associates with mitotic chromosomes and blocks cell division.

Intermolecular interactions between dimeric calcium-sensing receptor monomers are important for its normal function.

Identification of a putative effector protein for rab11 that participates in transferrin recycling.

Essential role of STAT3 for embryonic stem cell pluripotency.

The tail domain of lamin $Dm_{0}$ binds histones H2A and H2B

Regulation of endogenous E2F1 stability by the retinoblastoma family proteins.

Molecular evidence of cryptic speciation in planktonic foraminifers and their relation to oceanic provinces.

CORE-SINEs: eukaryotic short interspersed retroposing elements with common sequence motifs.

Relative rates of insertion and deletion mutations in a microsatellite sequence in cultured cells.

GLI3 mutations in human disorders mimic Drosophila cubitus interruptus protein functions and localization.

A cloning method to identify caspases and their regulators in yeast: identification of Drosophila IAP1 as an inhibitor of the Drosophila caspase DCP-1.

Periodical distribution of transcription factor sites in promoter regions and connection with chromatin structure.

The use of gene clusters to infer functional coupling.

Leishmania major Friedlin chromosome 1 has an unusual distribution of protein-coding genes.

Interpreting patterns of gene expression with self-organizing maps: Methods and application to hematopoietic differentiation

Isolation of DNA fragments associated with methylated CpG islands in human adenocarcinomas of the lung using a methylated DNA binding column and denaturing gradient gel electrophoresis.

Different TBX5 interactions in heart and limb defined by Holt-Oram syndrome mutations.

Regulation of the insulin-like developmental pathway of Caenorhabditis elegans by a homolog of the PTEN tumor suppressor gene.

A zinc finger truncation of murine WT1 results in the characteristic urogenital abnormalities of Denys-Drash syndrome.

Detecting patterns of protein distribution and gene expression in silico. (Journal: Proceedings of the National Academy of Sciences of the United States of America Volume: 96 Issue: 6)

Polarity of recombination in transformation of Streptococcus pneumoniae.

Abnormalities at 14q32.1 in T cell malignancies involve two oncogenes.

Mitotic recombination map of 13cen-13q14 derived from an investigation of loss of heterozygosity in retinoblastomas.

Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved.

Microsatellite instability in Drosophila spellchecker1 (MutS homolog) mutants.

Mutator phenotypes of yeast strains heterozygous for mutations in the MSH2 gene.

Functional differences between memory and naive CD8 T cells.

Vaccination with a recombinant vaccinia virus encoding a 'self' antigen induces autoimmune vitiligo and tumor cell destruction in mice: requirement for CD4(+) T lymphocytes.

Stable transduction of quiescent CD34(+)CD38(-) human hematopoietic cells by HIV-1-based lentiviral vectors.

Absence of tumor necrosis factor rescues RelA-deficient mice from embryonic lethality.

Position-dependent inhibition of class-switch recombination by PGK-neor cassettes inserted into the immunoglobulin heavy chain constant region locus.

Cyclophilin C-associated protein: a normal secreted glycoprotein that down-modulates endotoxin and proinflammatory responses in vivo.

Effective treatment of autoimmune disease and progressive renal disease by mixed bone-marrow transplantation that establishes a stable mixed chimerism in BXSB recipient mice.

Lymphocyte function-associated antigen-1 binding residues in intercellular adhesion molecule-2 (ICAM-2) and the integrin binding surface in the ICAM subfamily

Intercellular adhesion molecule-1 inhibits interleukin 4 production by naive T cells.

In vitro comparison of the antigen-binding and stability properties of the various molecular forms of IgA antibodies assembled and produced in CHO cells.

The Rho-family GTP exchange factor Vav is a critical transducer of T cell receptor signals to the calcium, ERK, and NF-kappaB pathways.

Novel mechanisms control the folding and assembly of λ5/14.1 and VpreB to produce an intact surrogate light chain

An inducible gene product for 6-phosphofructo-2-kinase with an AU-rich instability element: role in tumor cell glycolysis and the Warburg effect.

Mechanism of the cleavage specificity of Alzheimer’s disease γ-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein

Poly(ADP-ribose) polymerase-deficient mice are protected from streptozotocin-induced diabetes.

A model for studying megakaryocyte development and biology.

Vascular endothelial growth factor (VEGF)-like protein from orf virus NZ2 binds to VEGFR2 and neuropilin-1.

Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53.

Epidermal growth factor system regulates mucin production in airways.

Transforming growth factor beta stimulation of colorectal cancer cell lines: type II receptor bypass and changes in adhesion molecule expression.

Cooperative action of germ-line mutations in decorin and p53 accelerates lymphoma tumorigenesis.

Inhibition of growth, production of insulin-like growth factor-II (IGF-II), and expression of IGF-II mRNA of human cancer cell lines by antagonistic analogs of growth hormone-releasing hormone in vitro.

Transdermal photopolymerization for minimally invasive implantation.

Exposure of cryptic epitopes on transthyretin only in amyloid and in amyloidogenic mutants.

Molecular cloning and characterization of prostase, an androgen-regulated serine protease with prostate-restricted expression.

In vivo proliferation and cell cycle kinetics of long-term self-renewing hematopoietic stem cells.

Intravitreous transplantation of encapsulated fibroblasts secreting the human fibroblast growth factor 2 delays photoreceptor cell degeneration in Royal College of Surgeons rats.

Identification of mutations in the c-mpl gene in congenital amegakaryocytic thrombocytopenia.

Enhancement of fluid filtration across tumor vessels: Implication for delivery of macromolecules

Mechanism of increased iron absorption in murine model of hereditary hemochromatosis: increased duodenal expression of the iron transporter DMT1.

The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-A.

Spatial and temporal regulation of gap junction connexin43 in vascular endothelial cells exposed to controlled disturbed flows in vitro.

A model of human phenylalanine metabolism in normal subjects and in phenylketonuric patients.

Induced mutant mouse lines that express lipoprotein lipase in cardiac muscle, but not in skeletal muscle and adipose tissue, have normal plasma triglyceride and high-density lipoprotein-cholesterol levels.

Restriction of major surface protein 2 (MSP2) variants during tick transmission of the ehrlichia Anaplasma marginale.

Molecular and biophysical characterization of TT virus: evidence for a new virus family infecting humans.

Effects of changes in membrane sodium flux on virulence gene expression in Vibrio cholerae

The role of an alternative sigma factor in motility and pilus formation in the cyanobacterium Synechocystis sp. strain PCC6803

A genetic approach to trace neural circuits.

Functional repair of motor endplates after botulinum neurotoxin type A poisoning: biphasic switch of synaptic activity between nerve sprouts and their parent terminals.

Stimulus–secretion coupling in neurohypophysial nerve endings: A role for intravesicular sodium?

Antihyperalgesic effects of infection with a preproenkephalin-encoding herpes virus.

Cortical bitufted, horizontal, and Martinotti cells preferentially express and secrete reelin into perineuronal nets, nonsynaptically modulating gene expression.

Induction of utrophin gene expression by heregulin in skeletal muscle cells: role of the N-box motif and GA binding protein.

Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models.

Modulation of glycine receptors in retinal ganglion cells by zinc

Calcium/calmodulin-dependent protein kinase II is associated with the N-methyl-d-aspartate receptor

Stimulated changes in localized cerebral energy consumption under anesthesia.

The role of immunophilins in mutant superoxide dismutase-1linked familial amyotrophic lateral sclerosis

Measures of degeneracy and redundancy in biological networks.

Evidence for a physical interaction between presenilin and Notch

Ca2+/calmodulin-kinase II enhances channel conductance of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate type glutamate receptors.

Induction of an acetaminophen-sensitive cyclooxygenase with reduced sensitivity to nonsteroid antiinflammatory drugs.

Insulin increases near-membrane but not global $Ca^{2+}$ in isolated skeletal muscle

Insulin-like growth factor 1 is required for G2 progression in the estradiol-induced mitotic cycle.

EDS1, an essential component of R gene-mediated disease resistance in Arabidopsis has homology to eukaryotic lipases.

Channel-mediated high-affinity $K^{+}$ uptake into guard cells from Arabidopsis

Phenomenological theory of mortality evolution: its singularities, universality, and superuniversality.

Declining survival probability threatens the North Atlantic right whale.

Spatial attention affects brain activity in human primary visual cortex.

X chromosome evidence for ancient human histories.

Linguistic diversity of the Americas can be reconciled with a recent colonization.

Year: 1999 Volume: 96 Issue: 5

Year: 1999 Volume: 96 Issue: 4

Year: 1999 Volume: 96 Issue: 3

Year: 1999 Volume: 96 Issue: 2

Year: 1999 Volume: 96 Issue: 1

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

Induction of an acetaminophen-sensitive cyclooxygenase with reduced sensitivity to nonsteroid antiinflammatory drugs.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Botting, R. M. Robertson, P. M. Vane, J. R. Madsen, M. L. Simmons, D. L.
Description	Author Affiliation: Simmons DL ( Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602, USA. Dan_simmons@BYU.edu);
Abstract	The transformed monocyte/macrophage cell line J774.2 undergoes apoptosis when treated for 48 h with competitive inhibitors of cyclooxygenase (COX) isoenzymes 1 and 2. Many of these nonsteroid antiinflammatory drugs (NSAIDs), but in particular diclofenac, induce during this time period a COX activity that coincides with a robust induction of COX-2 protein. Induction of this activity requires high, apoptosis-inducing concentrations of diclofenac (>100 microM). Prolonged treatment of J774.2 cells with lower doses of diclofenac inhibits COX activity, indicating that diclofenac is a time-dependent, pseudoirreversible inhibitor of COX-2. It is difficult to wash out the inhibition. However, the activity evoked by high concentrations of diclofenac has a profoundly distinct COX active site that allows diclofenac, its inducer, to be washed readily from its active site. The diclofenac-induced activity also has the unusual property of being more sensitive to inhibition by acetaminophen (IC50 = 0.1-1.0 mM) than COX-2 induced with bacterial lipopolysaccharide. Moreover, relative to COX-1 or COX-2, diclofenac-induced enzyme activity shows significantly reduced sensitivity to inhibition by diclofenac or other competitively acting nonsteroid antiinflammatory drugs (NSAIDs) and the enzyme activity is insensitive to aspirin. If the robust induction of COX-2 observed is responsible for diclofenac-induced COX enzyme activity, it is clear that COX-2 can, therefore, exist in two catalytically active states. A luciferase reporter-construct that contains part of the COX-2 structure and binds into the membrane showed that chronic diclofenac treatment of fibroblasts results in marked mobilization of the fusion protein. Such a mobilization could result in enzymatically distinct COX-2 populations in response to chronic diclofenac treatment.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	6
Volume Number	96
Language	English
Publisher	National Academy of Sciences
Publisher Date	1999-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Anti-Inflammatory Agents, Non-Steroidal Pharmacology Diclofenac Drug Resistance Isoenzymes Metabolism Monocytes Drug Effects Prostaglandin-Endoperoxide Synthases Animals Apoptosis Cell Line, Transformed Cyclooxygenase 1 Cyclooxygenase 2 Enzyme Induction Membrane Proteins Mice Enzymology Pathology Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in