NDLI: Periodical distribution of transcription factor sites in promoter regions and connection with chromatin structure.

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Periodical distribution of transcription factor sites in promoter regions and connection with chromatin structure.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Trifonov, E. N. Ioshikhes, I. Zhang, M. Q.
Description	Author Affiliation: Ioshikhes I ( Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.);
Abstract	Nucleosomes regulate transcriptional initiation when positioned in the promoter area. This may require the transcription factor (TF) sites to be correlated with the nucleosome positions and phased on the nucleosome surface. If this is the case, one would expect a periodical distribution of TF sites in the vicinity of promoters, with the nucleosomal period of 10.1-10.5 bp. We examined the distributions of putative binding sites of 323 different TFs along 1, 057 sequences of the Eukaryotic Promoter Database (release 50) [Cavin Perier, R., Junier, T. & Bucher, P. (1998) Nucleic Acids Res. 26, 353-357] and of 218 TFs on 673 sequences of the Lead Exon Database of human promoter sequences. We obtained a statistically significant overrepresentation of TF sites distributed with the main period of 10.1-10.5 bp in the region -50 to +120 around the transcription start site and in few locations nearby. Correlation of the positioning of the TF sites with the nucleosomes is further reinforced by sequence-directed mapping of the nucleosomes, a method previously developed.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	6
Volume Number	96
Language	English
Publisher	National Academy of Sciences
Publisher Date	1999-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Chromatin Genetics Promoter Regions, Genetic Transcription Factors Transcription, Genetic Animals Binding Sites Ultrastructure Genome, Human Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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