NDLI: Stimulus–secretion coupling in neurohypophysial nerve endings: A role for intravesicular sodium?

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Stimulus–secretion coupling in neurohypophysial nerve endings: A role for intravesicular sodium?

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Pivovarova, N. B. Troadec, J. D. Thirion, S. Leapman, R. D. Andrews, S. B. Pagnotta, S. Nicaise, G.
Description	Author Affiliation: Thirion S ( Laboratoire de Physiologie Cellulaire et Moléculaire, and Centre Commun de Microscopie Appliquée, Faculté des Sciences, Université de Nice-Sophia Antipolis, 06108 Nice, France.);
Abstract	It is generally accepted that Ca is essentially involved in regulated secretion, but the role of this cation, as well as others such as Na, is not well understood. An illustrative example occurs in neurohypophysial secretion, where an experimentally induced increase in the cytosolic concentration of Na+ can induce continuous neuropeptide release. In contrast, an increase in cytosolic Ca2+ will have only a transient stimulatory effect. The secretion-promoting targets for Ca2+ are not known; they may be cytosolic, as is usually assumed, but they may also be intravesicular, especially in view of evidence that Ca-rich secretory vesicles are preferentially secreted. In the present work, we have investigated the movements of these cations into and out of secretory vesicles during stimulus-secretion coupling. Isolated rat neurohypophysial nerve endings were stimulated by potassium (55 mM) depolarization, and at 6 min (peak secretion) and 20 min after the onset of stimulation, the elemental content of individual secretory vesicles was measured by quantitative x-ray microanalysis. A depolarization-induced transient increase in intravesicular Na+ concentration was found to coincide with the onset of secretion. Moreover, only a predicted small fraction of peripheral vesicles-presumably the docked ones-were Na+-loaded. The low sulfur concentration of Na+-rich vesicles most likely resulted from vesicle swelling. The results suggest that high intravesicular Na+ concentrations in docked vesicles, occurring by Na+/Ca2+ exchange or by transient fusion pore opening, is a proximal event in exocytosis.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	6
Volume Number	96
Language	English
Publisher	National Academy of Sciences
Publisher Date	1999-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Calcium Physiology Cytoplasmic Granules Nerve Endings Pituitary Gland, Posterior Sodium Animals Ion Transport Membrane Potentials Ultrastructure Rats, Sprague-Dawley Rats, Wistar Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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