NDLI: Human cytomegalovirus harbors its own unique IL-10 homolog (cmvIL-10).

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Human cytomegalovirus harbors its own unique IL-10 homolog (cmvIL-10).

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Mirochnitchenko, O. V. Pestka, S. Kotenko, S. V. Saccani, S. Izotova, L. S.
Description	Author Affiliation: Kotenko SV ( Department of Molecular Genetics, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ 08854-5635, USA. kotenkse@umdnj.edu);
Abstract	We identified a viral IL-10 homolog encoded by an ORF (UL111a) within the human cytomegalovirus (CMV) genome, which we designated cmvIL-10. cmvIL-10 can bind to the human IL-10 receptor and can compete with human IL-10 for binding sites, despite the fact that these two proteins are only 27% identical. cmvIL-10 requires both subunits of the IL-10 receptor complex to induce signal transduction events and biological activities. The structure of the cmvIL-10 gene is unique by itself. The gene retained two of four introns of the IL-10 gene, but the length of the introns was reduced. We demonstrated that cmvIL-10 is expressed in CMV-infected cells. Thus, expression of cmvIL-10 extends the range of counter measures developed by CMV to circumvent detection and destruction by the host immune system.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	4
Volume Number	97
Language	English
Publisher	National Academy of Sciences
Publisher Date	2000-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cytomegalovirus Genetics Growth Substances Interleukin-10 Viral Proteins Amino Acid Sequence Animals Cell Line Cloning, Molecular Chemistry DNA-Binding Proteins Metabolism Genes, Viral Genome, Viral Leukocytes Major Histocompatibility Complex Molecular Sequence Data Protein Binding Receptors, Interleukin Receptors, Interleukin-10 STAT3 Transcription Factor Sequence Alignment Signal Transduction Trans-Activators Transfection Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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