NDLI: Suppression of chromosome segregation defects of Escherichia coli muk mutants by mutations in topoisomerase I.

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Suppression of chromosome segregation defects of Escherichia coli muk mutants by mutations in topoisomerase I.

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Suppression of chromosome segregation defects of Escherichia coli muk mutants by mutations in topoisomerase I.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Sawitzke, J. A. Austin, S.
Description	Author Affiliation: Sawitzke JA ( Advanced BioScience Laboratories Basic Research Program, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, MD 21702-1201, USA.);
Abstract	Escherichia coli muk mutants are temperature-sensitive and produce anucleate cells. A spontaneously occurring mutation was found in a DeltamukBkan mutant strain that suppressed the temperature-sensitive phenotype and mapped in or near topA, the gene that encodes topoisomerase I. Previously characterized topA mutations, topA10 and topA66, were found to be general suppressors of muk mutants: they suppressed temperature sensitivity and anucleate cell production of cells containing null or point mutations in mukB and null mutations in mukE or mukF. The suppression correlated with excess negative supercoiling by DNA gyrase, and the gyrase inhibitor, coumermycin, reversed it. Defects in topA allow 99% of cell division events in muk null mutants to proceed without chromosome loss or loss of cell viability. This observation imposes important limitations on models for Muk activity and is consistent with a role for MukBEF in chromosome folding and DNA condensation.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	4
Volume Number	97
Language	English
Publisher	National Academy of Sciences
Publisher Date	2000-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Chromosomal Proteins, Non-Histone Chromosome Aberrations DNA Topoisomerases, Type I Genetics Escherichia Coli Proteins Escherichia Coli Enzymology Repressor Proteins Aminocoumarins Bacterial Proteins Cell Division Cell Survival Coumarins Pharmacology DNA Topoisomerases, Type II Metabolism DNA, Superhelical Enzyme Inhibitors Histocytochemistry Mutation Suppression, Genetic Temperature Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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