NDLI: Bunyamwera bunyavirus nonstructural protein NSs is a nonessential gene product that contributes to viral pathogenesis.

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Bunyamwera bunyavirus nonstructural protein NSs is a nonessential gene product that contributes to viral pathogenesis.

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Bunyamwera bunyavirus nonstructural protein NSs is a nonessential gene product that contributes to viral pathogenesis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Elliott, R. M. Bridgen, A. Weber, F. Fazakerley, J. K.
Description	Author Affiliation: Bridgen A ( Division of Virology, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G11 5JR, Scotland, United Kingdom.);
Abstract	Bunyamwera virus (family Bunyaviridae, genus Bunyavirus) contains a tripartite negative-sense RNA genome. The smallest RNA segment, S, encodes the nucleocapsid protein N and a nonstructural protein, NSs, in overlapping reading frames. We have generated a mutant virus lacking NSs, called BUNdelNSs, by reverse genetics. Compared with the wild-type (wt) virus, BUNdelNSs exhibited a smaller plaque size and generated titers of virus approximately 1 log lower. In mammalian cells, the mutant expressed greatly increased levels of N protein; significantly, the marked inhibition of host cell protein synthesis shown by wt virus was considerably impaired by BUNdelNSs. When inoculated by the intracerebral route BUNdelNSs killed BALB/c mice with a slower time course than wt and exhibited a reduced cell-to-cell spread, and titers of virus in the brain were lower. In addition, the abrogation of NSs expression changed Bunyamwera virus from a noninducer to an inducer of an interferon-beta promoter. These results suggest that, although not essential for growth in tissue culture or in mice, the bunyavirus NSs protein has several functions in the virus life cycle and contributes to viral pathogenesis.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	2
Volume Number	98
Language	English
Publisher	National Academy of Sciences
Publisher Date	2001-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Bunyamwera Virus Genetics Viral Nonstructural Proteins Physiology Aedes Cytology Amino Acid Sequence Animals Brain Virology Pathogenicity Bunyaviridae Infections Cell Line Cricetinae Defective Viruses Embryo, Mammalian Embryo, Nonmammalian Gene Deletion Gene Expression Regulation, Viral Genes, Overlapping Genes, Reporter Interferon-beta Biosynthesis Kidney Mesocricetus Mice Mice, Inbred BALB C Molecular Sequence Data Nucleocapsid Nucleocapsid Proteins Promoter Regions, Genetic Protein Biosynthesis RNA, Viral Recombinant Fusion Proteins Specific Pathogen-Free Organisms Transfection Virulence Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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