NDLI: Serological detection of cutaneous T-cell lymphoma-associated antigens.

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Serological detection of cutaneous T-cell lymphoma-associated antigens.

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Serological detection of cutaneous T-cell lymphoma-associated antigens.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Dummer, R. Usener, D. Schadendorf, D. Eichmuller, S. Thiel, D. Stein, A.
Description	Author Affiliation: Eichmuller S ( German Cancer Research Center (DKFZ), Skin Cancer Unit (D0900), Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.);
Abstract	Cutaneous T-cell lymphomas (CTCL) are a group of skin neoplasms that originate from T lymphocytes and are difficult to treat in advanced stages. The present study is aimed at the identification of tumor-specific antigens from a human testis cDNA library using human sera known as the SEREX (serological identification of recombinantly expressed genes) approach. A cDNA library from normal testicle tissue was prepared and approximately 2 million recombinants were screened with sera from Sézary Syndrome and Mycosis fungoides patients. A total of 28 positive clones belonging to 15 different genes/ORFs were identified, including five hitherto unknown sequences. Whereas control sera did not react with most clones, 11-71% sera from CTCL patients were reactive against the identified clones. Expression analysis on 28 normal control and 17 CTCL tissues by reverse transcription-PCR (RT-PCR) and Northern blotting revealed seven ubiquitously distributed antigens, six differentially expressed antigens (several normal tissues were positive), and two tumor-specific antigens that were expressed only in testis and tumor tissues: (i) A SCP-1-like sequence, which has already been detected in various tumors, has been found in one CTCL tumor and four sera of CTCL patients reacted with various SCP-1-like clones and (ii) a new sequence named cTAGE-1 (CTCL-associated antigen 1) was detected in 35% of CTCL tumor tissues and sera of 6/18 patients reacted with this clone. The present study unravels CTCL-associated antigens independent of the T-cell receptor. The SCP-1-like gene and cTAGE-1 were shown to be immunogenic and immunologically tumor-specific and may therefore be candidates for immunotherapy targeting CTCL.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	2
Volume Number	98
Language	English
Publisher	National Academy of Sciences
Publisher Date	2001-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antibodies, Neoplasm Immunology Antigens, Neoplasm Mycosis Fungoides Neoplasm Proteins Sezary Syndrome Skin Neoplasms Antigens, Differentiation, T-Lymphocyte Genetics Blotting, Northern DNA, Complementary Expressed Sequence Tags Gene Expression Profiling Gene Expression Regulation, Neoplastic Gene Library Genes Membrane Glycoproteins Molecular Sequence Data Blood Nuclear Proteins Open Reading Frames Organ Specificity Recombinant Proteins Biosynthesis Reverse Transcriptase Polymerase Chain Reaction Sequence Homology, Nucleic Acid Testis Metabolism Comparative Study Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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