NDLI: Regulation of T-plastin expression by promoter hypomethylation in primary cutaneous T-cell lymphoma.

Please wait, while we are loading the content...

Array comparative genomic hybridization of keratoacanthomas and squamous cell carcinomas: different patterns of genetic aberrations suggest two distinct entities.

Chronic skin-specific inflammation promotes vascular inflammation and thrombosis.

Germline melanocortin-1-receptor genotype is associated with severity of cutaneous phenotype in congenital melanocytic nevi: a role for MC1R in human fetal development.

Toll-like receptor 3 ligand polyinosinic:polycytidylic acid promotes wound healing in human and murine skin.

GPHR-dependent functions of the Golgi apparatus are essential for the formation of lamellar granules and the skin barrier.

Bullous pemphigoid: simple measures for a complex disease.

Lamellar bodies: the key to cutaneous barrier function.

Melanocortin 1 receptor function: shifting gears from determining skin and nevus phenotype to fetal growth.

Toll-like receptors in wound healing: location, accessibility, and timing.

Year: 2012 Volume: 132 Issue: 7

Year: 2012 Volume: 132 Issue: 6

Year: 2012 Volume: 132 Issue: 5

Year: 2012 Volume: 132 Issue: 4

Year: 2012 Volume: 132 Issue: 3 Part 1

Year: 2012 Volume: 132 Issue: 3 Part 2

Year: 2012 Volume: 132 Issue: Supplementary 3

Year: 2012 Volume: 132 Issue: 2

Year: 2012 Volume: 132 Issue: 1

Year: 2012 Volume: 132 Issue: E1

Year: 2011 Volume: 131

Year: 2010 Volume: 130

Year: 2009 Volume: 129

Year: 2008 Volume: 128

Year: 2007 Volume: 127

Year: 2006 Volume: 126

Year: 2005 Volume: 125

Year: 2005 Volume: 124

Year: 2004 Volume: 123

Year: 2004 Volume: 122

Year: 2003 Volume: 121

Year: 2003 Volume: 120

Year: 2002 Volume: 119

Year: 2000 Volume: 115

Year: 2000 Volume: 114

Year: 1999 Volume: 112

Year: 1996 Volume: 106

Year: 1983 Volume: 80

Regulation of T-plastin expression by promoter hypomethylation in primary cutaneous T-cell lymphoma.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Jones, Christine L. Ferreira, Silvia McKenzie, Robert C. T. Tosi, Isabella Caesar, Jacqueline A. Bagot, Martine Whittaker, Sean J. Mitchell, Tracey J.
Description	Country affiliation: United kingdom Author Affiliation: Jones CL ( Skin Tumour Unit, St John's Institute of Dermatology, Division of Genetics and Molecular Medicine, King's College London, London, UK.)
Abstract	T-plastin (PLS3) is an actin-bundling protein normally expressed in epithelial cells but absent in cells of hematopoietic origin. Aberrant PLS3 expression has been demonstrated in lymphocytes from Sézary syndrome (SS) patients and has been proposed as a biomarker for SS; however, the mechanism underlying dysregulation of PLS3 has not been determined. In this study, PLS3 mRNA expression was demonstrated in 21/35 (60%) SS patients and in 3/8 (38%) mycosis fungoides patients, all of whom had clonal blood involvement. No evidence for PLS3 mutations within coding or promoter regions was found, but significant hypomethylation of CpG dinucleotides 95-99 within the PLS3 CpG island was observed and this was restricted to the PLS3+ population. A polyclonal antibody specific to PLS3 was raised to examine coexpression of PLS3 with a panel of T-cell differentiation markers. All PLS3+ cells were CD3+CD4+ and CD26-, suggesting that loss of CD26 is consistently associated with gain of PLS3, whereas all other markers were distributed heterogeneously. However, a patient-specific TCR copy number assay also demonstrated heterogeneity in PLS3 expression in tumor cell populations. Importantly, our findings demonstrate PLS3 expression in the majority of SS patients and provide insight into the molecular regulation of PLS3 expression in CTCL.
File Format	HTM / HTML
ISSN	0022202X
e-ISSN	15231747
Journal	Journal of Investigative Dermatology
Issue Number	8
Volume Number	132
Language	English
Publisher	Elsevier
Publisher Date	2012-08-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Dermatology Dna Methylation Gene Expression Regulation, Neoplastic Lymphoma, T-cell, Cutaneous Genetics Metabolism Membrane Glycoproteins Biosynthesis Microfilament Proteins Promoter Regions, Genetic Antigens, Cd3 Antigens, Cd4 Biological Markers Cpg Islands Dipeptidyl Peptidase 4 Mutation Mycosis Fungoides Nucleotides Rna, Messenger Sezary Syndrome Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Molecular Biology Dermatology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

MicroRNA expression profiling and DNA methylation signature for deregulated microRNA in cutaneous T-cell lymphoma.

T-plastin (PLS3) gene expression differentiates Sézary syndrome from mycosis fungoides and inflammatory skin diseases and can serve as a biomarker to monitor disease progression.

Increased Programmed Death-1 Expression on CD4+ T Cells in Cutaneous T-Cell Lymphoma: Implications for Immune Suppression

Mycosis Fungoides–Type Cutaneous T-Cell Lymphoma and Neutrophilic Dermatosis

Brentuximab as a Treatment for CD30+ Mycosis Fungoides and Sézary Syndrome

Patterns of Gene Expression in Cutaneous T-Cell Lymphoma: Systematic Review of Transcriptomic Studies in Mycosis Fungoides

Genome-wide analysis of cutaneous T-cell lymphomas identifies three clinically relevant classes.

Downregulation of Fas gene expression in Sézary syndrome is associated with promoter hypermethylation.

The Ectopic Expression of Meiosis Regulatory Genes in Cutaneous T-Cell Lymphomas (CTCL)

Regulation of T-plastin expression by promoter hypomethylation in primary cutaneous T-cell lymphoma.

Similar Documents

MicroRNA expression profiling and DNA methylation signature for deregulated microRNA in cutaneous T-cell lymphoma.

T-plastin (PLS3) gene expression differentiates Sézary syndrome from mycosis fungoides and inflammatory skin diseases and can serve as a biomarker to monitor disease progression.

Increased Programmed Death-1 Expression on CD4+ T Cells in Cutaneous T-Cell Lymphoma: Implications for Immune Suppression

Mycosis Fungoides–Type Cutaneous T-Cell Lymphoma and Neutrophilic Dermatosis

Brentuximab as a Treatment for CD30+ Mycosis Fungoides and Sézary Syndrome

Patterns of Gene Expression in Cutaneous T-Cell Lymphoma: Systematic Review of Transcriptomic Studies in Mycosis Fungoides

Genome-wide analysis of cutaneous T-cell lymphomas identifies three clinically relevant classes.

Downregulation of Fas gene expression in Sézary syndrome is associated with promoter hypermethylation.

The Ectopic Expression of Meiosis Regulatory Genes in Cutaneous T-Cell Lymphomas (CTCL)

Regulation of T-plastin expression by promoter hypomethylation in primary cutaneous T-cell lymphoma.