NDLI: Analysis of gene expression during myc oncogene-induced lymphomagenesis in the bursa of Fabricius.

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Analysis of gene expression during myc oncogene-induced lymphomagenesis in the bursa of Fabricius.

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Analysis of gene expression during myc oncogene-induced lymphomagenesis in the bursa of Fabricius.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Thomas, S. J. Neiman, P. E. Burnside, J. Delrow, J. Ruddell, A. Jasoni, C. Brandvold, K. A. Loring, G.
Description	Author Affiliation: Neiman PE ( Divisions of Basic Sciences and Human Biology, Fred Hutchinson Cancer Research Center and the Departments of Medicine and Pathology, University of Washington, 1100 Fairview Avenue North, Seattle, WA 98109-1024, USA. pneiman@fhcrc.org);
Abstract	The transcriptional effects of deregulated myc gene overexpression are implicated in tumorigenesis in a spectrum of experimental and naturally occurring neoplasms. In follicles of the chicken bursa of Fabricius, myc induction of B-cell neoplasia requires a target cell population present during early bursal development and progresses through preneoplastic transformed follicles to metastatic lymphomas. We developed a chicken immune system cDNA microarray to analyze broad changes in gene expression that occur during normal embryonic B-cell development and during myc-induced neoplastic transformation in the bursa. The number of mRNAs showing at least 3-fold change was greater during myc-induced lymphomagenesis than during normal development, and hierarchical cluster analysis of expression patterns revealed that levels of several hundred mRNAs varied in concert with levels of myc overexpression. A set of 41 mRNAs were most consistently elevated in myc-overexpressing preneoplastic and neoplastic cells, most involved in processes thought to be subject to regulation by Myc. The mRNAs for another cluster of genes were overexpressed in neoplasia independent of myc expression level, including a small subset with the expression signature of embryonic bursal lymphocytes. Overexpression of myc, and some of the genes overexpressed with myc, may be important for generation of preneoplastic transformed follicles. However, expression profiles of late metastatic tumors showed a large variation in concert with myc expression levels, and some showed minimal myc overexpression. Therefore, high-level myc overexpression may be more important in the early induction of these lymphomas than in maintenance of late-stage metastases.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	11
Volume Number	98
Language	English
Publisher	National Academy of Sciences
Publisher Date	2001-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Bursa Of Fabricius Gene Expression Profiling Gene Expression Regulation, Neoplastic Genes, Myc Physiology Lymphoma, B-Cell Genetics Animals Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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