NDLI: BimD/SPO76 is at the interface of cell cycle progression, chromosome morphogenesis, and recombination

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BimD/SPO76 is at the interface of cell cycle progression, chromosome morphogenesis, and recombination

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BimD/SPO76 is at the interface of cell cycle progression, chromosome morphogenesis, and recombination

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zickler, D. Heyting, C. Kafer, E. John, T. Van Aalderen, M. Van Heemst, D.
Description	Author Affiliation: van Heemst D ( Institut de Génétique et Microbiologie, UMR 8621, Université Paris Sud, 91405 Orsay Cedex, France.);
Abstract	BIMD of Aspergillus nidulans belongs to a highly conserved protein family implicated, in filamentous fungi, in sister-chromatid cohesion and DNA repair. We show here that BIMD is chromosome associated at all stages, except from late prophase through anaphase, during mitosis and meiosis, and is involved in several aspects of both programs. First, bimD(+) function must be executed during S through M. Second, in bimD6 germlings, mitotic nuclear divisions and overall cellular program occur more rapidly than in wild type. Thus, BIMD, an abundant chromosomal protein, is a negative regulator of normal cell cycle progression. Third, bimD6 reduces the level of mitotic interhomolog recombination but does not alter the ratio between crossover and noncrossover outcomes. Moreover, bimD6 is normal for intrachromosomal recombination. Therefore, BIMD is probably not involved in the enzymology of recombinational repair per se. Finally, during meiosis, staining of the Sordaria ortholog Spo76p delineates robust chromosomal axes, whereas BIMD stains all chromatin. SPO76 and bimD are functional homologs with respect to their roles in mitotic chromosome metabolism but not in meiosis. We propose that BIMD exerts its diverse influences on cell cycle progression as well as chromosome morphogenesis and recombination by modulating chromosome structure.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	11
Volume Number	98
Language	English
Publisher	National Academy of Sciences
Publisher Date	2001-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Aspergillus Nidulans Genetics Chromosomes, Fungal Fungal Proteins Physiology Recombination, Genetic Saccharomyces Cerevisiae Proteins Drug Effects Metabolism Cell Cycle Cell Cycle Proteins G1 Phase Genes, Fungal Heating Meiosis Methyl Methanesulfonate Pharmacology Mitosis Morphogenesis Mutagenesis Mutagens S Phase Sordariales Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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