NDLI: Corepressor-induced organization and assembly of the biotin repressor: a model for allosteric activation of a transcriptional regulator.

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Corepressor-induced organization and assembly of the biotin repressor: a model for allosteric activation of a transcriptional regulator.

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Corepressor-induced organization and assembly of the biotin repressor: a model for allosteric activation of a transcriptional regulator.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kwon, K. Matthews, B. W. Beckett, D. Weaver, L. H.
Description	Author Affiliation: Weaver LH ( Institute for Molecular Biology, Howard Hughes Medical Institute and Department of Physics, 1229 University of Oregon, Eugene, OR 97403-1229, USA. brian@uoxray.uoregon.edu);
Abstract	The Escherichia coli biotin repressor binds to the biotin operator to repress transcription of the biotin biosynthetic operon. In this work, a structure determined by x-ray crystallography of a complex of the repressor bound to biotin, which also functions as an activator of DNA binding by the biotin repressor (BirA), is described. In contrast to the monomeric aporepressor, the complex is dimeric with an interface composed in part of an extended beta-sheet. Model building, coupled with biochemical data, suggests that this is the dimeric form of BirA that binds DNA. Segments of three surface loops that are disordered in the aporepressor structure are located in the interface region of the dimer and exhibit greater order than was observed in the aporepressor structure. The results suggest that the corepressor of BirA causes a disorder-to-order transition that is a prerequisite to repressor dimerization and DNA binding.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	11
Volume Number	98
Language	English
Publisher	National Academy of Sciences
Publisher Date	2001-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Bacterial Proteins Metabolism Biotin Carbon-Nitrogen Ligases Escherichia Coli Proteins Operator Regions, Genetic Repressor Proteins Trans-Activators Transcription Factors Transcriptional Activation Allosteric Regulation Chemistry Dimerization Models, Molecular Molecular Sequence Data Mutagenesis, Site-Directed Protein Structure, Secondary Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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