NDLI: Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth.

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Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth.

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Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Gadiparthi, Seshu Leong, Paul L. Robbins, Paul D. Johnson, Daniel E. Xi, Sichuan Watkins, Simon F. Dyer, Kevin F. Mai, Jeffrey C. Andrews, Genevieve A. Burke, Nancy A. Grandis, Jennifer Rubin
Description	Author Affiliation: Leong PL ( Department of Otolaryngology, University of Pittsburgh School of Medicine and University of Pittsburgh Cancer Institute, Pittsburgh, PA 15260, USA.);
Abstract	The transcription factor signal transducer and activator of transcription 3 (Stat3) is constitutively activated in a variety of cancers including squamous cell carcinoma of the head and neck (SCCHN). Previous investigations have demonstrated that activated Stat3 contributes to a loss of growth control and transformation. To investigate the therapeutic potential of blocking Stat3 in cancer cells, we developed a transcription factor decoy to selectively abrogate activated Stat3. The Stat3 decoy was composed of a 15-mer double-stranded oligonucleotide, which corresponded closely to the Stat3 response element within the c-fos promoter. The Stat3 decoy bound specifically to activated Stat3 and blocked binding of Stat3 to a radiolabeled Stat3 binding element. By contrast, a mutated version of the decoy that differed by only a single base pair did not bind the activated Stat3 protein. Treatment of head and neck cancer cells with the Stat3 decoy inhibited proliferation and Stat3-mediated gene expression, but did not decrease the proliferation of normal oral keratinocytes. Thus, disruption of activated Stat3 by using a transcription factor decoy approach may serve as a novel therapeutic strategy for cancers characterized by constitutive Stat3 activation.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	7
Volume Number	100
Language	English
Publisher	National Academy of Sciences
Publisher Date	2003-04-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Apoptosis Drug Effects Carcinoma, Squamous Cell Pathology DNA-Binding Proteins Antagonists & Inhibitors Head And Neck Neoplasms Oligodeoxyribonucleotides, Antisense Pharmacology Trans-Activators Cell Division Genetics Luciferases Metabolism Proto-Oncogene Proteins C-bcl-2 STAT3 Transcription Factor Tumor Cells, Cultured Bcl-X Protein Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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