NDLI: The structural basis for biphasic kinetics in the folding of the WW domain from a formin-binding protein: lessons for protein design?

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The structural basis for biphasic kinetics in the folding of the WW domain from a formin-binding protein: lessons for protein design?

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Brooks, Charles L. Karanicolas, John
Description	Author Affiliation: Karanicolas J ( Department of Molecular Biology (TPC6), The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.);
Abstract	The mechanism of formation of beta-sheets is of great importance because of the significant role of such structures in the initiation and propagation of amyloid diseases. In this study we examine the folding of a series of three-stranded antiparallel beta-sheets known as WW domains. Whereas other WW domains have been shown to fold with single-exponential kinetics, the WW domain from murine formin-binding protein 28 has recently been shown to fold with biphasic kinetics. By using a combination of kinetics and thermodynamics to characterize a simple model for this protein, the origins of the biphasic kinetics is found to lie in the fact that most of the protein is able to fold without requiring one of the beta-hairpins to be correctly registered. The correct register of this hairpin is enforced by a surface-exposed hydrophobic contact, which is not present in other WW domains. This finding suggests the use of judiciously chosen surface-exposed hydrophobic pairs as a protein design strategy for enforcing the desired strand registry.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	7
Volume Number	100
Language	English
Publisher	National Academy of Sciences
Publisher Date	2003-04-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Carrier Proteins Chemistry Metabolism Amino Acid Sequence Binding Sites Kinetics Mathematics Models, Molecular Models, Theoretical Molecular Sequence Data Peptide Fragments Protein Folding Thermodynamics Transcriptional Elongation Factors Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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