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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Darnell, J. E. Shen, Y. Bromberg, J. F. Devgan, G. |
| Description | Author Affiliation: Shen Y ( Laboratory of Molecular Cell Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.); |
| Abstract | Stats1 and 3 (signal transducers and activators of transcription) can be activated simultaneously, although not necessarily to the same degree or duration, by the interaction of cells with the same polypeptide ligand (EGF, PDGF, or high concentrations of IL-6, for example). However, these two Stat proteins can mediate opposing effects on cell growth and survival. Stat1 activation slows growth and promotes apoptosis. In contrast, activated Stat3 can protect cells from apoptosis. Furthermore, a constitutively active form of Stat3, Stat3-C (bridged by S-S linkages between cysteines instead of phosphotyrosines) can induce cellular transformation of fibroblasts. We have determined that fibroblasts transformed by Stat3-C are more resistant to proapoptotic stimuli than nontransformed cells. Also, to examine the potential opposing roles in apoptosis of Stat1 and Stat3, we studied the cervical carcinoma-derived cell line, Me180, which undergoes Stat1-dependent, IFN gamma-induced apoptosis. Me180 cells that express Stat3-C are protected against IFN gamma-mediated apoptosis. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 4 |
| Volume Number | 98 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2001-02-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Apoptosis DNA-Binding Proteins Metabolism Signal Transduction Trans-Activators 3T3 Cells Animals Cell Line, Transformed Culture Media, Serum-Free Genetics Fibroblasts Cytology Growth Inhibitors Pharmacology Interferon-gamma Mice Oncogene Protein Pp60(v-src) Proto-Oncogene Proteins Proto-Oncogene Proteins C-bcl-2 STAT1 Transcription Factor STAT3 Transcription Factor Tumor Cells, Cultured Ultraviolet Rays Bcl-2-Associated X Protein Bcl-X Protein Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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