NDLI: Context sensitivity of activity-dependent increases in cerebral blood flow.

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Context sensitivity of activity-dependent increases in cerebral blood flow.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Gold, Lorenz Caesar, Kirsten Lauritzen, Martin
Description	Author Affiliation: Caesar K ( Department of Medical Physiology, The Panum Institute, University of Copenhagen, Blegdamsvej 3, 2000 Copenhagen N, Denmark.);
Abstract	Functional neuroimaging in humans is used widely to study brain function in relation to human disease and cognition. The neural basis of neuroimaging signals is probably synaptic activity, but the effect of context, defined as the interaction between synaptic inhibition, excitation, and the electroresponsive properties of the targeted neurons, is not well understood. We examined here the effect of interaction of synaptic excitation and net inhibition on the relationship between electrical activity and vascular signals in the cerebellar cortex. We show that stimulation of the net inhibitory parallel fibers simultaneously with stimulation of the excitatory climbing fibers leads to a further rise in total local field potentials (LFP) and cerebral blood flow (CBF) amplitudes, not a decrease, as predicted from theoretical studies. However, the combined stimulation of the parallel and climbing fiber systems produced changes in CBF and LFP that were smaller than their algebraic sum evoked by separate stimulation of either system. This finding was independent of the starting condition, i.e., whether inhibition was superimposed on a state of excitation or vice versa. The attenuation of the increases in LFP and CBF amplitudes was similar, suggesting that synaptic activity and CBF were coupled under these conditions. The result might be explained by a relative neuronal refractoriness that relates to the intrinsic membrane properties of Purkinje cells, which determine the recovery time of these cells. Our work implies that neuronal and vascular signals are context-sensitive and that their amplitudes are modulated by the electroresponsive properties of the targeted neurons.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	7
Volume Number	100
Language	English
Publisher	National Academy of Sciences
Publisher Date	2003-04-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Blood Flow Velocity Physiology Brain Cerebrovascular Circulation Animals Blood Supply Electric Stimulation Laser-Doppler Flowmetry Membrane Potentials Microelectrodes Olivary Nucleus Purkinje Cells Rats, Wistar Synapses Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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