NDLI: Male-biased transmission of deleterious mutations to the progeny in Arabidopsisthaliana

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Male-biased transmission of deleterious mutations to the progeny in Arabidopsisthaliana

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Male-biased transmission of deleterious mutations to the progeny in Arabidopsisthaliana

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Whittle, Carrie-ann Johnston, Mark O.
Description	Author Affiliation: Whittle CA ( Department of Biology, Dalhousie University, 1355 Oxford Street, Halifax, NS, Canada B3H 4J1. whitc@dal.ca);
Abstract	The extent and cause of male-biased mutation rates, the higher number of mutations in sperm than in eggs, is currently an active and controversial subject. Recent evidence indicates that this male (sperm) bias not only occurs in animals but also in plants. The higher mutation rate in plant sperm was inferred from rates of evolution of neutral DNA regions, and the results were confined to the mitochondria and chloroplasts of gymnosperms. However, the relative transmission rates of deleterious mutations, which have substantial evolutionary consequences, have rarely been studied. Here, an investigation is described by using the hermaphroditic self-compatible flowering plant Arabidopsis thaliana, in which we artificially increased the rate of mutation in pollen (i.e., sperm donor) and maternal (i.e., egg donor) parents, by using two kinds of UV irradiation in parallel and separate experiments, and assessed the deleterious effects on fitness of the F(2) generation. The results show that more deleterious induced mutations are transmitted to the progeny by a sperm than by an egg. These findings provide the first experimental evidence that more deleterious mutations are inherited from sperm than from an egg in any organism. Possible causes underlying this male bias are discussed.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	7
Volume Number	100
Language	English
Publisher	National Academy of Sciences
Publisher Date	2003-04-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Arabidopsis Genetics Biological Evolution DNA, Mitochondrial DNA, Plant Mutation Pollen Physiology Ultraviolet Rays Radiation Effects Chloroplasts Crosses, Genetic Mitochondria Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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