NDLI: Meeting of the minds: Metalloneurochemistry

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Binding and release of iron by gel-encapsulated human transferrin: evidence for a conformational search.

Hg(II) binding to a weakly associated coiled coil nucleates an encoded metalloprotein fold: a kinetic analysis.

Functional copper at the acetyl-CoA synthase active site

Interdomain zinc site on human albumin

Non-heme iron enzymes: Contrasts to heme catalysis

A rhodium(III) complex for high-affinity DNA base-pair mismatch recognition.

Microsecond electrophoresis.

Prospective identification of tumorigenic breast cancer cells.

Essential function of alpha-calcium/calmodulin-dependent protein kinase II in neurotransmitter release at a glutamatergic central synapse.

Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo.

Variable character of O—O and M—O bonding in side-on $(η^{2})$ 1:1 metal complexes of $O_{2}$

Purified particulate methane monooxygenase from Methylococcus capsulatus (Bath) is a dimer with both mononuclear copper and a copper-containing cluster.

A gain-of-function mutation in ftsA bypasses the requirement for the essential cell division gene zipA in Escherichia coli.

Opening protein pores with chaotropes enhances Fe reduction and chelation of Fe from the ferritin biomineral

A solution to the worn tooth conundrum in primate functional anatomy.

Demonstration of functional coupling between gamma -aminobutyric acid (GABA) synthesis and vesicular GABA transport into synaptic vesicles.

Promyogenic members of the Ig and cadherin families associate to positively regulate differentiation.

Floating plant dominance as a stable state.

Mammalian basal metabolic rate is proportional to body $mass^{2/3}$

An engineered two-iron superoxide reductase lacking the $[Fe(SCys)_{4}]$ site retains its catalytic properties in vitro and invivo

Yeast genetic selections to optimize RNA decoys for transcription factor NF-kappa B.

Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth.

Insight into the mechanism of aromatic hydroxylation by toluene 4-monooxygenase by use of specifically deuterated toluene and p-xylene.

Histone deacetylase inhibitors prevent oxidative neuronal death independent of expanded polyglutamine repeats via an Sp1-dependent pathway.

Lymphocyte surface thiol levels.

Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants.

Ring-like pore structures of SecA: implication for bacterial protein-conducting channels.

A regulatory protein that interferes with activator-stimulated transcription in bacteria.

Antibody-enhanced pneumococcal adherence requires IgA1 protease.

Dealing with iron: common structural principles in proteins that transport iron and heme.

Interconversion of two oxidized forms of taurine/α-ketoglutarate dioxygenase, a non-heme iron hydroxylase: Evidence for bicarbonate binding

Electron-nuclear double resonance spectroscopy (and electron spin-echo envelope modulation spectroscopy) in bioinorganic chemistry.

Bifunctional antisense oligonucleotides provide a trans-acting splicing enhancer that stimulates SMN2 gene expression in patient fibroblasts.

Impaired adrenocorticotropic hormone response to bacterial endotoxin in mice deficient in prostaglandin E receptor EP1 and EP3 subtypes.

Convergent evolution of perenniality in rice and sorghum

The role of disulfide bonds in the assembly and function of MD-2

A duodenally absorbable CXC chemokine receptor 4 antagonist, KRH-1636, exhibits a potent and selective anti-HIV-1 activity.

Speculative synthetic chemistry and the nitrogenase problem.

The organometallic active site of [Fe]hydrogenase: Models and entatic states

Electrochemical and NMR spectroscopic studies of distal pocket mutants of nitrophorin 2: Stability, structure, and dynamics of axial ligand complexes

ARC5, a cytosolic dynamin-like protein from plants, is part of the chloroplast division machinery.

Regulation of Dlx3 gene expression in visceral arches by evolutionarily conserved enhancer elements.

Real-time semantic compensation in patients with agrammatic comprehension: electrophysiological evidence for multiple-route plasticity.

Cell and tumor classification using gene expression data: construction of forests.

Cloning and engineering of the cinnamycin biosynthetic gene cluster from Streptomyces cinnamoneus cinnamoneus DSM 40005.

Statistically relevant conserved quantities for truncated quasigeostrophic flow.

Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor.

Lanthanide-binding helix-turn-helix peptides: solution structure of a designed metallonuclease.

Rapid evolution of the neutralizing antibody response to HIV type 1 infection.

Induction of G1 cycle arrest in T lymphocytes results in increased extracellular levels of beta-chemokines: a strategy to inhibit R5 HIV-1.

Induction of bilirubin clearance by the constitutive androstane receptor (CAR).

Efficient active transport of gene nanocarriers to the cell nucleus.

Introduction and characterization of a functionally linked metal ion binding site at the exposed heme edge of myoglobin

An $Fe^{IV}O$ complex of a tetradentate tripodal nonheme ligand

Kinetics of proton-coupled electron-transfer reactions to the manganese-oxo “cubane” complexes containing the $Mn_{4}O$ and $Mn_{4}O$ core types

Structural effects of quinacrine binding in the open channel of the acetylcholine receptor.

The LIM-only protein FHL2 is a serum-inducible transcriptional coactivator of AP-1.

Gapped DNA is anisotropically bent.

Designing isoform-specific peptide disruptors of protein kinase A localization.

Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: a disease susceptibility polymorphism.

Property gamma factors and the Hochschild cohomology problem.

Posterior parietal cortex and the filtering of distractors.

Transforming growth factor beta 1 inhibits expression of NKp30 and NKG2D receptors: consequences for the NK-mediated killing of dendritic cells.

Mineralized tissue and vertebrate evolution: the secretory calcium-binding phosphoprotein gene cluster.

The protein-folding speed limit: intrachain diffusion times set by electron-transfer rates in denatured Ru(NH3)5(His-33)-Zn-cytochrome c.

A macrocyclic zinc(II) fluorophore as a detector of apoptosis

Inducible protein knockout reveals temporal requirement of CaMKII reactivation for memory consolidation in the brain.

A soluble protein is immobile in dormant spores of Bacillus subtilis but is mobile in germinated spores: implications for spore dormancy.

Gigantic cannibals driving a whole-lake trophic cascade.

The CsrR/CsrS two-component system of group A Streptococcus responds to environmental $Mg^{2+}$

The influence of the synergistic anion on iron chelation by ferric binding protein, a bacterial transferrin

Dietary zinc modulates gene expression in murine thymus: results from a comprehensive differential display screening.

Phosphatidylinositol 4-kinase type IIalpha is responsible for the phosphatidylinositol 4-kinase activity associated with synaptic vesicles.

Neuregulin 1-erbB2 signaling is required for the establishment of radial glia and their transformation into astrocytes in cerebral cortex.

Processive DNA synthesis observed in a polymerase crystal suggests a mechanism for the prevention of frameshift mutations.

A model of the glycine receptor deduced from Brownian dynamics studies.

Calpain regulates neutrophil chemotaxis.

Nutritional supplement chromium picolinate causes sterility and lethal mutations in Drosophila melanogaster.

Synthetic modeling of zinc thiolates: Quantitative assessment of hydrogen bonding in modulating sulfur alkylation rates

Global and specific transcriptional repression by the histone H3 amino terminus in yeast.

Importance of the CNGA4 channel gene for odor discrimination and adaptation in behaving mice.

Anatomical organization of forward fiber projections from area TE to perirhinal neurons representing visual long-term memory in monkeys.

Somatic hypermutation of the B cell receptor genes B29 (Igbeta, CD79b) and mb1 (Igalpha, CD79a).

Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis.

Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase.

Distinct roles of dopamine D2L and D2S receptor isoforms in the regulation of protein phosphorylation at presynaptic and postsynaptic sites.

The birth and evolution of surface science: child of the union of science and technology.

Structure and membrane affinity of a suite of amphiphilic siderophores produced by a marine bacterium.

The retinitis pigmentosa GTPase regulator (RPGR)- interacting protein: subserving RPGR function and participating in disk morphogenesis.

Structural elements of metal selectivity in metal sensor proteins.

A redox switch in CopC: an intriguing copper trafficking protein that binds copper(I) and copper(II) at different sites.

Emergency response to an anthrax attack.

Dynamic behavior of paired claudin strands within apposing plasma membranes.

Transcriptome dynamics of Deinococcus radiodurans recovering from ionizing radiation.

Genetic characterization of glucose transporter function in Leishmania mexicana.

Tuning the free-energy landscape of a WW domain by temperature, mutation, and truncation.

Domain organization of the type 1 inositol 1,4,5-trisphosphate receptor as revealed by single-particle analysis.

Canonical and unconventional pairing schemes between bis(nucleobase) complexes of trans-a2PtII: artificial nucleobase quartets and C-H...N bonds.

Clonal tracking of autoaggressive T cells in polymyositis by combining laser microdissection, single-cell PCR, and CDR3-spectratype analysis.

Neuron recognition by parallel Potts segmentation.

Sequence information can be obtained from single DNA molecules.

The structural basis for biphasic kinetics in the folding of the WW domain from a formin-binding protein: lessons for protein design?

The history of effective population size and genetic diversity in the Yellowstone grizzly (Ursus arctos): implications for conservation.

Visualizing the $Ca^{2+}-dependent$ activation of gelsolin by using synchrotron footprinting

Macula densa cell signaling involves ATP release through a maxi anion channel

A metal-binding site in the catalytic subunit of anaerobic ribonucleotide reductase.

Toll-like receptor 4 on stromal and hematopoietic cells mediates innate resistance to uropathogenic Escherichia coli.

Bioinorganic chemistry in the postgenomic era.

Neutral thiol as a proximal ligand to ferrous heme iron: implications for heme proteins that lose cysteine thiolate ligation on reduction.

Superoxo, mu-peroxo, and mu-oxo complexes from heme/O2 and heme-Cu/O2 reactivity: copper ligand influences in cytochrome c oxidase models.

New clues for platinum antitumor chemistry: kinetically controlled metal binding to DNA.

The role of copper and protons in heme-copper oxidases: Kinetic study of an engineered heme-copper center in myoglobin

Salmochelins, siderophores of Salmonella enterica and uropathogenic Escherichia coli strains, are recognized by the outer membrane receptor IroN.

Metal stoichiometry and functional studies of the diphtheria toxin repressor

The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment.

The bioinorganic chemistry of iron in oxygenases and supramolecular assemblies.

Evidence against the presence of an anandamide transporter.

Pitx3 is required for development of substantia nigra dopaminergic neurons.

Mouse ribonucleotide reductase R2 protein: a new target for anaphase-promoting complex-Cdh1-mediated proteolysis.

Critical role of oxidative stress in estrogen-induced carcinogenesis.

Recombination signal sequence-binding protein Jκ alters mesodermal cell fate decisions by suppressing cardiomyogenesis

Enterobactin: an archetype for microbial iron transport.

Analysis of the eye developmental pathway in Drosophila using DNA microarrays.

Identification and functional characterization of a novel binding site on TNF-alpha promoter.

Context sensitivity of activity-dependent increases in cerebral blood flow.

Investigation of metal-dithiolate fold angle effects: implications for molybdenum and tungsten enzymes.

Nitric oxide binding at the mononuclear active site of reduced Pyrococcus furiosus superoxide reductase

How does cyanide inhibit superoxide reductase? Insight from synthetic $Fe^{III}N_{4}S$ model complexes

Meeting of the minds: Metalloneurochemistry

Misfolded CuZnSOD and amyotrophic lateral sclerosis.

Male-biased transmission of deleterious mutations to the progeny in Arabidopsisthaliana

Preorganization of molecular binding sites in designed diiron proteins.

Why the kidney glomerulus does not clog: a gel permeation/diffusion hypothesis of renal function.

Enhanced oxygen diffusivity in interfaces of nanocrystalline ZrO2.Y2O3.

Biological inorganic chemistry at the beginning of the 21st century.

Progress in understanding functional imaging signals.

Molten globules move into action.

Ultrafast capillary electrophoresis and bioanalytical applications.

Meeting halfway on the bridge between protein folding theory and experiment.

Breast cancer stem cells revealed.

Dynamin: the endosymbiosis ring of power?

Looking at teeth in a new light.

Genome-wide analysis of mRNA translation profiles in Saccharomyces cerevisiae.

At the interface of inorganic chemistry and biology.

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Meeting of the minds: Metalloneurochemistry

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lippard, Stephen J. Burdette, Shawn C.
Description	Author Affiliation: Burdette SC ( Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.);
Abstract	Metalloneurochemistry is the study of metal ion function in the brain and nervous system at the molecular level. Research in this area is exemplified through discussion of several forefront areas where significant progress has been made in recent years. The structure and function of ion channels have been elucidated through high-resolution x-ray structural work on the bacterial K(+) ion channel. Selection of potassium over sodium ions is achieved by taking advantage of key principles of coordination chemistry. The role of calcium ions in neuronal signal transduction is effected by several Ca(2+)-binding protein such as calmodulin, calcineurin, and synaptotagmin. Structural changes in response to calcium ion concentrations allow these proteins to function in memory formation and other neurochemical roles. Metallochaperones help to achieve metal ion homeostasis and thus prevent neurological diseases because of metal ion imbalance. Much detailed chemical information about these systems has become available recently. Zinc is another important metal ion in neuroscience. Its concentration in brain is in part controlled by metallothionein, and zinc is released in the hippocampus at glutamatergic synapses. New fluorescent sensors have become available to help track such zinc release.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	7
Volume Number	100
Language	English
Publisher	National Academy of Sciences
Publisher Date	2003-04-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Ion Channels Physiology Metalloproteins Metabolism Neurochemistry Animals Antiporters Chemistry Calcium Carrier Proteins Models, Molecular Protein Structure, Secondary Synapses Synaptic Transmission Zinc Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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