NDLI: A low molecular weight mimic of the Toll/IL-1 receptor/resistance domain inhibits IL-1 receptor-mediated responses.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2003 Volume: 100 Issue: 26

Year: 2003 Volume: 100 Issue: 25

Year: 2003 Volume: 100 Issue: 24

Year: 2003 Volume: 100 Issue: 23

Year: 2003 Volume: 100 Issue: 22

Year: 2003 Volume: 100 Issue: 21

Year: 2003 Volume: 100 Issue: 20

Year: 2003 Volume: 100 Issue: 19

Year: 2003 Volume: 100 Issue: 18

Year: 2003 Volume: 100 Issue: 17

Year: 2003 Volume: 100 Issue: 16

Year: 2003 Volume: 100 Issue: 15

Year: 2003 Volume: 100 Issue: 14

Year: 2003 Volume: 100 Issue: 13

Division site selection in Escherichia coli involves dynamic redistribution of Min proteins within coiled structures that extend between the two cell poles.

Effective behavioral treatment of focal hand dystonia in musicians alters somatosensory cortical organization.

Lateral gene transfer and the evolution of plastid-targeted proteins in the secondary plastid-containing alga Bigelowiella natans.

Expression profiles of acute lymphoblastic and myeloblastic leukemias with ALL-1 rearrangements.

Oncogenic potential of TASK3 (Kcnk9) depends on $K^{+}$ channel function

Expression of prestin-homologous solute carrier (SLC26) in auditory organs of nonmammalian vertebrates and insects.

A lupus-like syndrome develops in mice lacking the Ro 60-kDa protein, a major lupus autoantigen.

The complete genome sequence of Mycobacterium bovis.

Masquerading as self? Endoparasitic Strepsiptera (Insecta) enclose themselves in host-derived epidermal bag.

Physical interaction between RRS1-R, a protein conferring resistance to bacterial wilt, and PopP2, a type III effector targeted to the plant nucleus.

Germ-line transgenesis of the Tc1/mariner superfamily transposon Minos in Ciona intestinalis.

End-sequence profiling: sequence-based analysis of aberrant genomes.

Maspin expression inhibits osteolysis, tumor growth, and angiogenesis in a model of prostate cancer bone metastasis.

Reset of human neocortical oscillations during a working memory task.

Nanobacteria-like calcite single crystals at the surface of the Tataouine meteorite.

Evidence for neurogenesis in the adult mammalian substantia nigra.

Selective impairment of hippocampal neurogenesis by chronic alcoholism: protective effects of an antioxidant.

Validation of the hexose transporter of Plasmodium falciparum as a novel drug target.

A simple energy-conserving system: proton reduction coupled to proton translocation.

Selenium-deficient diet enhances protein oxidation and affects methionine sulfoxide reductase (MsrB) protein level in certain mouse tissues.

Synthetic small molecules that control stem cell fate.

Genera of the human lineage.

The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase.

The terminal nucleotide of the Mu genome controls catalysis of DNA strand transfer.

Nutrient loading and consumers: agents of change in open-coast macrophyte assemblages.

Connectivity optimization and the positioning of cortical areas.

Relationship of herpes simplex virus genome configuration to productive and persistent infections.

Mast cells disrupt epithelial barrier function during enteric nematode infection.

Runx3 and Runx1 are required for CD8 T cell development during thymopoiesis.

Spreading of Sir3 protein in cells with severe histone H3 hypoacetylation.

RNA recognition by designed peptide fusion creates 'artificial' tRNA synthetase.

Function and glycosylation of plant-derived antiviral monoclonal antibody.

High-resolution structure of RNase P protein from Thermotoga maritima.

A low molecular weight mimic of the Toll/IL-1 receptor/resistance domain inhibits IL-1 receptor-mediated responses.

Comparative sequencing of human and chimpanzee MHC class I regions unveils insertions/deletions as the major path to genomic divergence.

Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: the MPAKT model.

A newly discovered cholesteryl galactoside from Borrelia burgdorferi.

Suppressed catalytic activity of base excision repair enzymes on rotationally positioned uracil in nucleosomes.

Developing an energy landscape for the novel function of a (beta/alpha)8 barrel: ammonia conduction through HisF.

Control of in vitro organogenesis by cyclin-dependent kinase activities in plants.

Systematic discovery of multicomponent therapeutics.

Stepwise cytoskeletal polarization as a series of checkpoints in innate but not adaptive cytolytic killing.

Protein tyrosine phosphatase RQ is a phosphatidylinositol phosphatase that can regulate cell survival and proliferation.

Male Japanese quails with female brains do not show male sexual behaviors.

T-bet is required for optimal production of IFN-gamma and antigen-specific T cell activation by dendritic cells.

Efficient biotinylation and single-step purification of tagged transcription factors in mammalian cells and transgenic mice.

Origin and evolutionary process of the CNS elucidated by comparative genomics analysis of planarian ESTs.

Genes encoding putative natural killer cell C-type lectin receptors in teleostean fishes.

Carbohydrate-dependent signaling from the phosphatidylglucoside-based microdomain induces granulocytic differentiation of HL60 cells.

Direct molecular haplotyping of long-range genomic DNA with M1-PCR.

piggyBac-based insertional mutagenesis in the presence of stably integrated P elements in Drosophila.

Impairment of reward-related learning by cholinergic cell ablation in the striatum.

Allosteric control of internal electron transfer in cytochrome cd1 nitrite reductase.

A multistep mechanism for the activation of rearrangement in the immune system

TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation.

Detailed map of a cis-regulatory input function.

CD40 ligand is a critical effector of Epstein-Barr virus in host cell survival and transformation.

Mapping of quantitative trait loci controlling trypanotolerance in a cross of tolerant West African N'Dama and susceptible East African Boran cattle

Myoblasts transplanted into rat infarcted myocardium are functionally isolated from their host.

Evidence that mouse brain neuropathy target esterase is a lysophospholipase.

The interplay of glycosylation and disulfide formation influences fibrillization in a prion protein fragment

The coiled-coil of the human Rad50 DNA repair protein contains specific segments of increased flexibility.

Fast gating in the Shaker $K^{+}$ channel and the energy landscape of activation

Tetraspanin CD151 regulates alpha6beta1 integrin adhesion strengthening.

Regression of established tumors and metastases by potent vascular endothelial growth factor blockade.

Structural determinant of TRPV1 desensitization interacts with calmodulin.

Single-molecule detection of DNA hybridization.

Inducible nitric oxide synthase expression inhibition by adenovirus E1A

Recombinant lymphocytic choriomeningitis virus expressing vesicular stomatitis virus glycoprotein

Targeted cytosine methylation for in vivo detection of protein-DNA interactions.

Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing.

Prediction and measurement of an autoregulatory genetic module.

Effect of insulin on human skeletal muscle mitochondrial ATP production, protein synthesis, and mRNA transcripts.

Social interaction shapes babbling: testing parallels between birdsong and speech.

Small nucleolar RNA interference induced by antisense or double-stranded RNA in trypanosomatids.

From latent disseminated cells to overt metastasis: genetic analysis of systemic breast cancer progression.

Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2.

Understanding folding and design: replica-exchange simulations of 'Trp-cage' miniproteins.

Crystal structure of the SOS cell division inhibitor SulA and in complex with FtsZ.

Mdm20 protein functions with Nat3 protein to acetylate Tpm1 protein and regulate tropomyosin-actin interactions in budding yeast.

Gene function analysis in environmental isolates: the nif regulon of the strict iron oxidizing bacterium Leptospirillum ferrooxidans.

Direct activation of the apoptosis machinery as a mechanism to target cancer cells.

Membrane-binding and activation mechanism of PTEN.

Discovery of a fusion kinase in EOL-1 cells and idiopathic hypereosinophilic syndrome

Comparative genomics of Physcomitrella patens gametophytic transcriptome and Arabidopsis thaliana: implication for land plant evolution.

Expression of utrophin A mRNA correlates with the oxidative capacity of skeletal muscle fiber types and is regulated by calcineurin/NFAT signaling.

The evolution of vertebrate blood coagulation as viewed from a comparison of puffer fish and sea squirt genomes.

Modeling of DNA microarray data by using physical properties of hybridization.

Horizontal gene transfer in eukaryotic algal evolution.

Retuning the misfiring brain.

What happens if the room at the bottom runs out? A close look at small water pores.

Replication of the herpes simplex virus genome: does it really go around in circles?

Epigenetic inactivation of CHFR in human tumors.

Mechanotransduction and flow across the endothelial glycocalyx.

Bacterial cell division spirals into control.

Determination of the membrane topology of Ost4p and its subunit interactions in the oligosaccharyltransferase complex in Saccharomyces cerevisiae.

Brain repair by cell replacement and regeneration.

Human acetyl-CoA carboxylase 1 gene: presence of three promoters and heterogeneity at the 5'-untranslated mRNA region.

Mifepristone (RU486) protects Purkinje cells from cell death in organotypic slice cultures of postnatal rat and mouse cerebellum

Pronounced reduction in adenoma recurrence associated with aspirin use and a polymorphism in the ornithine decarboxylase gene.

Deletion of histidine triad nucleotide-binding protein 1/PKC-interacting protein in mice enhances cell growth and carcinogenesis.

The complete genome sequence of the carcinogenic bacterium Helicobacter hepaticus.

Caspase 8 small interfering RNA prevents acute liver failure in mice.

An unusual type IB topoisomerase from African trypanosomes.

Human and mouse genomic sequences reveal extensive breakpoint reuse in mammalian evolution.

Differential proteasomal processing of hydrophobic and hydrophilic protein regions: Contribution to cytotoxic T lymphocyte epitope clustering in HIV-1-Nef

Alginate is not a significant component of the extracellular polysaccharide matrix of PA14 and PAO1 Pseudomonas aeruginosa biofilms.

Additive effects of simulated climate changes, elevated $CO_{2},$ and nitrogen deposition on grassland diversity

Transglutaminase 2-/- mice reveal a phagocytosis-associated crosstalk between macrophages and apoptotic cells.

A pattern analysis of the second Rehnquist U.S. Supreme Court.

Year: 2003 Volume: 100 Issue: 12

Year: 2003 Volume: 100 Issue: 11

Year: 2003 Volume: 100 Issue: 10

Year: 2003 Volume: 100 Issue: 9

Year: 2003 Volume: 100 Issue: 8

Year: 2003 Volume: 100 Issue: 7

Year: 2003 Volume: 100 Issue: 6

Year: 2003 Volume: 100 Issue: 5

Year: 2003 Volume: 100 Issue: 4

Year: 2003 Volume: 100 Issue: 3

Year: 2003 Volume: 100 Issue: 2

Year: 2003 Volume: 100 Issue: Suppl 2

Year: 2003 Volume: 100 Issue: 1

Year: 2003 Volume: 100 Issue: Suppl 1

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

A low molecular weight mimic of the Toll/IL-1 receptor/resistance domain inhibits IL-1 receptor-mediated responses.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Pemberton, Janell Shivanyuk, Alexander Rebek, Julius Behrens, M. Margarita Bartfai, Tamas Gaidarova, Svetlana
Description	Author Affiliation: Bartfai T ( Department of Neuropharmacology, The Harold L. Dorris Neurological Research Center, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. tbartfai@scripps.edu);
Abstract	Toll-like receptors (TLRs) and the type I IL-1 receptor (IL-1RI) are key components of the innate immune system activated by microbial infections and inflammation. The signaling cascade from agonist-occupied TLRs and IL-1Rs involves recruitment of the small cytosolic adapter protein MyD88 that binds to IL-1RI via homotypic interactions mediated by Toll/IL-1R/resistance (TIR) domains. Dominant negative forms and null mutations of MyD88 have recently been shown to preclude bacterial product or IL-1-mediated activation of NF-kappaB pathways, demonstrating that MyD88 is an essential component of the Toll receptor signaling. Here, we report the synthesis and pharmacological effects of a low molecular weight MyD88 mimic, hydrocinnamoyl-l-valyl pyrrolidine (compound 4a), modeled on a tripeptide sequence of the BB-loop [(F/Y)-(V/L/I)-(P/G)] of the TIR domain. Results are presented showing that compound 4a interferes with the interactions between mouse MyD88 and IL-1RI at the TIR domains. Compound 4a inhibited IL-1beta-induced phosphorylation of the mitogen-activated protein kinase p38 in EL4 thymoma cells and in freshly isolated murine lymphocytes in a concentration-dependent manner. In vivo, compound 4a produced a significant attenuation of the IL-1beta-induced fever response (200 mg/kg, i.p.). Inhibition of the TIR domain-mediated MyD88/IL1-RI interaction by a low molecular weight, cell-penetrating TIR domain mimic suggests an intracellular site for antiinflammatory drug action.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	13
Volume Number	100
Language	English
Publisher	National Academy of Sciences
Publisher Date	2003-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antigens, Differentiation Chemistry Pyrrolidines Pharmacology Receptors, Immunologic Receptors, Interleukin-1 Valine Adaptor Proteins, Signal Transducing Animals Blotting, Western Densitometry Enzyme-Linked Immunosorbent Assay Genes, Dominant Interleukin-1 Metabolism Lipopolysaccharides Mice Mice, Inbred C57BL Mitogen-Activated Protein Kinases Models, Chemical Models, Molecular Mutation Myeloid Differentiation Factor 88 Precipitin Tests Protein Binding Protein Structure, Tertiary Chemical Synthesis Antagonists & Inhibitors Signal Transduction Spleen Time Factors Tumor Cells, Cultured Analogs & Derivatives P38 Mitogen-Activated Protein Kinases Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in