NDLI: A newly discovered cholesteryl galactoside from Borrelia burgdorferi.

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A newly discovered cholesteryl galactoside from Borrelia burgdorferi.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Yergey, Alfred Ben-menachem, Gil Schneerson, Rachel Kubler-kielb, Joanna Coxon, Bruce
Description	Author Affiliation: Ben-Menachem G ( Laboratory of Developmental and Molecular Immunity, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. gilben@nih.gov);
Abstract	Two major glycolipids, which comprise approximately 36% of the total lipid mass from Borrelia burgdorferi, the etiological agent of Lyme disease, were investigated. We determined the fatty acid type, sugar identity, anomeric configuration, and substituent type and position. The structures were identified as cholesteryl 6-O-acyl-beta-d-galactopyranoside (B. burgdorferi glycolipid 1, BbGL-I), and 1,2-di-O-acyl-3-O-alpha-d-galactopyranosyl-sn-glycerol (BbGL-II). The major fatty acids were palmitate and oleate. The structures were corroborated by gas-liquid chromatography MS, matrix-assisted laser desorption/ionization time-of-flight spectroscopy, fast atom bombardment MS, detailed NMR spectrometry, and metabolic labeling. This is a previously undescribed demonstration of a cholesteryl galactoside in bacteria. Lipopolysaccharide was not detected in B. burgdorferi. The two glycolipids have several properties suggesting they may function as lipopolysaccharide: both are main components of the bacterial membrane, surface exposed, and have a three-domain structure. BbGL-I elicited specific antibodies in mice and rabbits, and BbGL-II elicited antibodies that reacted with both glycolipids.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	13
Volume Number	100
Language	English
Publisher	National Academy of Sciences
Publisher Date	2003-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Borrelia Burgdorferi Metabolism Cholesterol Chemistry Galactosides Glycolipids Saponins Animals Carbohydrate Sequence Chromatography, Gas Chromatography, Liquid Chromatography, Thin Layer Enzyme-Linked Immunosorbent Assay Galactose Glycerol Lipid Metabolism Lipopolysaccharides Magnetic Resonance Spectroscopy Methylation Mice Models, Chemical Molecular Sequence Data Oleic Acid Palmitates Protein Structure, Tertiary Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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