NDLI: Regression of established tumors and metastases by potent vascular endothelial growth factor blockade.

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Regression of established tumors and metastases by potent vascular endothelial growth factor blockade.

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Regression of established tumors and metastases by potent vascular endothelial growth factor blockade.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kandel, Jessica J. O'toole, Kathleen Rudge, John S. Yancopoulos, George D. Yamashiro, Darrell J. Serur, Anna Mccrudden, Kimberly W. Zabski, Stephanie New, Tamara Yokoi, Akiko Huang, Jianzhong Frischer, Jason S. Kadenhe, Angela Holash, Jocelyn
Description	Author Affiliation: Huang J ( Division of Pediatric Surgery, Department of Pathology, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA.);
Abstract	Vascular endothelial growth factor (VEGF) is a critical promoter of blood vessel growth during embryonic development and tumorigenesis. To date, studies of VEGF antagonists have primarily focused on halting progression in models of minimal residual cancer. Consistent with this focus, recent clinical trials suggest that blockade of VEGF may impede cancer progression, presumably by preventing neoangiogenesis. However, VEGF is also a key mediator of endothelial-vascular mural cell interactions, a role that may contribute to the integrity of mature vessels in advanced tumors. Here, we report that high-affinity blockade of VEGF, using the recently described VEGF-Trap, abolishes mature, preexisting vasculature in established xenografts. Eradication of vasculature is followed by marked tumor regression, including regression of lung micrometastases. Thus, the contribution of relatively low levels of VEGF to vessel integrity may be critical to maintenance of even very small tumor masses. Potent blockade of VEGF may provide a new therapeutic option for patients with bulky, metastatic cancers.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	13
Volume Number	100
Language	English
Publisher	National Academy of Sciences
Publisher Date	2003-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antineoplastic Agents Pharmacology Endothelial Growth Factors Antagonists & Inhibitors Metabolism Intercellular Signaling Peptides And Proteins Lymphokines Neoplasms Drug Therapy Recombinant Fusion Proteins Actins Animals Antigens, CD31 Biosynthesis Apoptosis Blood Platelets Disease Progression Endothelium, Vascular Cytology Immunohistochemistry In Situ Hybridization In Situ Nick-End Labeling Lectins Lung Neoplasms Mice Mice, Nude Microscopy, Confocal Muscle, Smooth Necrosis Neoplasm Metastasis Neoplasm Transplantation Neovascularization, Pathologic Perfusion Receptors, Vascular Endothelial Growth Factor Time Factors Tumor Cells, Cultured Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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