NDLI: Fast gating in the Shaker $K^{+}$ channel and the energy landscape of activation

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Fast gating in the Shaker $K^{+}$ channel and the energy landscape of activation

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Sigg, Daniel Bezanilla, Francisco Stefani, Enrico
Description	Author Affiliation: Sigg D ( Division of Molecular Medicine, Departments of Anesthesiology and Physiology, and Brain Research Institute, David Geffen School of Medicine, University of California, Los Angeles, CA 90095-1778, USA.);
Abstract	An early component of the gating current in Shaker K+ channels with a time constant of approximately 12 microsec has been recorded with a high-speed patch-clamp setup. This fast component was found to be part of the gating current associated with the opening and closing of the channel. With regard to an energy-landscape interpretation of protein kinetics, the voltage and temperature dependence of the fast component may be explained by a combination of drift diffusion and barrier jumping in the initial stages of channel activation. The data were modeled by a gating particle undergoing Brownian motion in a one-dimensional diffusion landscape that featured diminishing electrical resistance and entropy in the direction of channel activation. The final open state of the channel was reasoned to be narrow and deep to account for successful subtraction of linear-charge displacements at positive potentials. The overall picture of gating that emerges from these studies is that the channel experiences incremental organization from a relaxed state in the early steps of activation to a rigidly structured open state.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	13
Volume Number	100
Language	English
Publisher	National Academy of Sciences
Publisher Date	2003-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Potassium Channels Chemistry Animals Biophysical Phenomena Biophysics DNA, Complementary Metabolism Entropy Ions Kinetics Membrane Potentials Oocytes RNA, Messenger Shaker Superfamily Of Potassium Channels Temperature Thermodynamics Time Factors Xenopus Laevis Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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