NDLI: Selective impairment of hippocampal neurogenesis by chronic alcoholism: protective effects of an antioxidant.

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Selective impairment of hippocampal neurogenesis by chronic alcoholism: protective effects of an antioxidant.

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Selective impairment of hippocampal neurogenesis by chronic alcoholism: protective effects of an antioxidant.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Muriach, Maria Romero, Francisco J. Yague, Almudena G. Collado-morente, Lucia Herrera, Daniel G. Bosch-morell, Francisco Johnsen-soriano, Siv Garcia-verdugo, J. Manuel
Description	Author Affiliation: Herrera DG ( Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA. dah2007@med.cornell.edu);
Abstract	A major pathogenic mechanism of chronic alcoholism involves oxidative burden to liver and other cell types. We show that adult neurogenesis within the dentate gyrus of the hippocampus is selectively impaired in a rat model of alcoholism, and that it can be completely prevented by the antioxidant ebselen. Rats fed for 6 weeks with a liquid diet containing moderate doses of ethanol had a 66.3% decrease in the number of new neurons and a 227-279% increase in cell death in the dentate gyrus as compared with paired controls. Neurogenesis within the olfactory bulb was not affected by alcohol. Our studies indicate that alcohol abuse, even for a short duration, results in the death of newly formed neurons within the adult brain and that the underlying mechanism is related to oxidative or nitrosative stress. Moreover, these findings suggest that the impaired neurogenesis may be a mechanism mediating cognitive deficits observed in alcoholism.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	13
Volume Number	100
Language	English
Publisher	National Academy of Sciences
Publisher Date	2003-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Alcoholism Antioxidants Pharmacology Ethanol Adverse Effects Hippocampus Drug Effects Animals Antimetabolites Azoles Bromodeoxyuridine Cell Division Cell Survival Pathology Microscopy, Electron Neurons Neuroprotective Agents Nitrogen Metabolism Olfactory Bulb Organoselenium Compounds Oxidative Stress Rats, Sprague-Dawley Time Factors Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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