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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Wang, Chia-fang Kuo, Hung-chih Hsu, Lea Chia-ling Chou, Shen-ju Chang, Ching-pu Touboul, Jonathan D. Nam, Sean Cui, Yi |
| Description | Author Affiliation: Hsu LC ( Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, 115, Taiwan); Nam S ( Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, 115, Taiwan); Cui Y ( Collège de France, Centre for Interdisciplinary Research in Biology, CNRS UMR 7241, INSERM U1050, MemoLife Paris Science Lettres, 75231 Paris, France); Chang CP ( Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, 115, Taiwan); Wang CF ( Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, 115, Taiwan); Kuo HC ( Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, 115, Taiwan); Touboul JD ( Collège de France, Centre for Interdisciplinary Research in Biology, CNRS UMR 7241, INSERM U1050, MemoLife Paris Science Lettres, 75231 Paris, France); Chou SJ ( Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, 115, Taiwan); |
| Abstract | The timing of cortical neurogenesis has a major effect on the size and organization of the mature cortex. The deletion of the LIM-homeodomain transcription factor Lhx2 in cortical progenitors by Nestin-cre leads to a dramatically smaller cortex. Here we report that Lhx2 regulates the cortex size by maintaining the cortical progenitor proliferation and delaying the initiation of neurogenesis. The loss of Lhx2 in cortical progenitors results in precocious radial glia differentiation and a temporal shift of cortical neurogenesis. We further investigated the underlying mechanisms at play and demonstrated that in the absence of Lhx2, the Wnt/ß-catenin pathway failed to maintain progenitor proliferation. We developed and applied a mathematical model that reveals how precocious neurogenesis affected cortical surface and thickness. Thus, we concluded that Lhx2 is required for ß-catenin function in maintaining cortical progenitor proliferation and controls the timing of cortical neurogenesis. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 39 |
| Volume Number | 112 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2015-09-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Cerebral Cortex Embryology Gene Expression Regulation, Developmental Genetics LIM-Homeodomain Proteins Metabolism Models, Neurological Neurogenesis Physiology Transcription Factors Animals Computer Simulation DNA Primers Galactosides HEK293 Cells In Situ Hybridization Indoles Luciferases Mice Mice, Knockout Real-Time Polymerase Chain Reaction Wnt Signaling Pathway Beta Catenin Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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