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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Nave, Klaus-armin Garratt, Alistair N. Grigoryan, Tamara Wende, Hagen Birchmeier, Carmen Qi, Jingjing Birchmeier, Walter Stein, Simone |
| Description | Author Affiliation: Grigoryan T ( Cancer Research Program and Neuroscience Program, Max Delbrück Center for Molecular Medicine, 13125 Berlin, Germany.); |
| Abstract | During late Schwann cell development, immature Schwann cells segregate large axons from bundles, a process called 'axonal radial sorting.' Here we demonstrate that canonical Wnt signals play a critical role in radial sorting and assign a role to Wnt and Rspondin ligands in this process. Mice carrying ß-catenin loss-of-function mutations show a delay in axonal sorting; conversely, gain-of-function mutations result in accelerated sorting. Sorting deficits are accompanied by abnormal process extension, differentiation, and aberrant cell cycle exit of the Schwann cells. Using primary cultured Schwann cells, we analyze the upstream effectors, Wnt and Rspondin ligands that initiate signaling, and downstream genetic programs that mediate the Wnt response. Our analysis contributes to a better understanding of the mechanisms of Schwann cell development and fate decisions. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 45 |
| Volume Number | 110 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2013-11-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Axons Physiology Cell Lineage Schwann Cells Thrombospondins Metabolism Wnt Signaling Pathway Beta Catenin Animals Blotting, Western DNA Primers Genetics Flow Cytometry In Situ Hybridization Mice Mice, Transgenic Microarray Analysis Mutation Paracrine Communication Real-Time Polymerase Chain Reaction Sciatic Nerve Ultrastructure Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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