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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Brooke, Basil D. Deschietere, Johan Ranson, Hilary Osinga, Anne J. Mnyone, Ladslaus L. Farenhorst, Marit Snetselaar, Janneke Knols, Bart G. J. Suer, Remco A. Andriessen, Rob Lyimo, Issa N. |
| Spatial Coverage | Africa |
| Description | Author Affiliation: Andriessen R ( In2Care BV, Wageningen 6709 PG, The Netherlands); Snetselaar J ( In2Care BV, Wageningen 6709 PG, The Netherlands); Suer RA ( In2Care BV, Wageningen 6709 PG, The Netherlands); Osinga AJ ( In2Care BV, Wageningen 6709 PG, The Netherlands); Deschietere J ( CTF2000, Zele 9240, Belgium); Lyimo IN ( Environmental Health and Ecological Sciences Thematic Group, Ifakara Health Institute, Ifakara, Tanzania); Mnyone LL ( Environmental Health and Ecological Sciences Thematic Group, Ifakara Health Institute, Ifakara, Tanzania); Brooke BD ( Wits Research Institute for Malaria, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2050, South Africa); Ranson H ( Department of Vector Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, United Kingdom.); Knols BG ( In2Care BV, Wageningen 6709 PG, The Netherlands); Farenhorst M ( In2Care BV, Wageningen 6709 PG, The Netherlands); |
| Abstract | Insecticide resistance poses a significant and increasing threat to the control of malaria and other mosquito-borne diseases. We present a novel method of insecticide application based on netting treated with an electrostatic coating that binds insecticidal particles through polarity. Electrostatic netting can hold small amounts of insecticides effectively and results in enhanced bioavailability upon contact by the insect. Six pyrethroid-resistant Anopheles mosquito strains from across Africa were exposed to similar concentrations of deltamethrin on electrostatic netting or a standard long-lasting deltamethrin-coated bednet (PermaNet 2.0). Standard WHO exposure bioassays showed that electrostatic netting induced significantly higher mortality rates than the PermaNet, thereby effectively breaking mosquito resistance. Electrostatic netting also induced high mortality in resistant mosquito strains when a 15-fold lower dose of deltamethrin was applied and when the exposure time was reduced to only 5 s. Because different types of particles adhere to electrostatic netting, it is also possible to apply nonpyrethroid insecticides. Three insecticide classes were effective against strains of Aedes and Culex mosquitoes, demonstrating that electrostatic netting can be used to deploy a wide range of active insecticides against all major groups of disease-transmitting mosquitoes. Promising applications include the use of electrostatic coating on walls or eave curtains and in trapping/contamination devices. We conclude that application of electrostatically adhered particles boosts the efficacy of WHO-recommended insecticides even against resistant mosquitoes. This innovative technique has potential to support the use of unconventional insecticide classes or combinations thereof, potentially offering a significant step forward in managing insecticide resistance in vector-control operations. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 39 |
| Volume Number | 112 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2015-09-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Culicidae Drug Effects Insecticide Resistance Physiology Insecticides Toxicity Malaria Prevention & Control Mosquito Nets Pyrethrins Africa Animals Biological Availability Nitriles Static Electricity Time Factors Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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