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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Mcpherson, Jacob G. Miller, Robert R. Perlmutter, Steve I. |
| Description | Author Affiliation: McPherson JG ( Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195.); Miller RR ( Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195.); Perlmutter SI ( Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195 perl@uw.edu.); |
| Abstract | Use-dependent movement therapies can lead to partial recovery of motor function after neurological injury. We attempted to improve recovery by developing a neuroprosthetic intervention that enhances movement therapy by directing spike timing-dependent plasticity in spared motor pathways. Using a recurrent neural-computer interface in rats with a cervical contusion of the spinal cord, we synchronized intraspinal microstimulation below the injury with the arrival of functionally related volitional motor commands signaled by muscle activity in the impaired forelimb. Stimulation was delivered during physical retraining of a forelimb behavior and throughout the day for 3 mo. Rats receiving this targeted, activity-dependent spinal stimulation (TADSS) exhibited markedly enhanced recovery compared with animals receiving targeted but open-loop spinal stimulation and rats receiving physical retraining alone. On a forelimb reach and grasp task, TADSS animals recovered 63% of their preinjury ability, more than two times the performance level achieved by the other therapy groups. Therapeutic gains were maintained for 3 additional wk without stimulation. The results suggest that activity-dependent spinal stimulation can induce neural plasticity that improves behavioral recovery after spinal cord injury. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 39 |
| Volume Number | 112 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2015-09-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Cervical Cord Injuries Neuronal Plasticity Physiology Physical Therapy Modalities Recovery Of Function Spinal Cord Injuries Therapy Animals Electric Stimulation Electromyography Rehabilitation Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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