NDLI: Antigenotoxic effect of the Plumbago zeylanica extract against the genotoxic damage induced by potassium canrenoate in cultured human peripheral blood lymphocytes.

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Antigenotoxic effect of the Plumbago zeylanica extract against the genotoxic damage induced by potassium canrenoate in cultured human peripheral blood lymphocytes.

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Year: 2012 Volume: 35 Issue: 1

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Antigenotoxic effect of the Plumbago zeylanica extract against the genotoxic damage induced by potassium canrenoate in cultured human peripheral blood lymphocytes.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Siddique, Yasir H. Ara, Gulshan Beg, Tanveer Afzal, Mohammad Faisal, Mohammad
Spatial Coverage	India
Description	Country affiliation: India Author Affiliation: Siddique YH ( Human Genetics and Toxicology Laboratory, Section of Genetics, Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, India. yasir_hasansiddique@rediffmail.com)
Abstract	In India, natural preparations derived from the plants are widely use for the treatments of various diseases. Hence, it becomes necessary to assess the modulating action of the plant extract when associated with other substances. Potassium canrenoate (PC) is a synthetic steroid and is used in the treatment of hypertension. It is not only a genotoxic agent, but also a tumor-initiating agent. In the present study, the effect of various doses (i.e., 5, 10, 20, and 30 µM) of PC were studied for their genotoxic effects in the presence of S9 mix in cultured human lymphocytes, using mitotic index, chromosomal aberrations, sister chromatid exchanges, and replication index as parameters. PC was found to be genotoxic at 20 and 30 µM. Treatment of 30 µM of PC was given along with different doses of Plumbago zeylanica extract (i.e., 107.5, 212.5, 315, and 417 µg/mL) of the culture medium. A dose-dependent decrease in the genotoxic effects of PC was observed. The result suggested that the plant extract per se does not have genotoxic potential, but can modulate the genotoxicity of PC in cultured human lymphocytes.
File Format	HTM / HTML
ISSN	01480545
Issue Number	2
Volume Number	35
e-ISSN	15256014
Journal	Drug and Chemical Toxicology
Language	English
Publisher	Taylor & Francis
Publisher Date	2012-04-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Toxicology Canrenoic Acid Toxicity Leukocytes, Mononuclear Drug Effects Mutagens Plant Extracts Pharmacology Plumbaginaceae Chemistry Antagonists & Inhibitors Cell Cycle Cell Proliferation Chromosome Aberrations Chemically Induced Drug Interactions Humans India Isolation & Purification Sister Chromatid Exchange Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health Toxicology Pharmacology Chemical Health and Safety

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Antigenotoxic effect of the Plumbago zeylanica extract against the genotoxic damage induced by potassium canrenoate in cultured human peripheral blood lymphocytes.

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