NDLI: Role of curcumin on chloroquine phosphate-induced reproductive toxicity.

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Role of curcumin on chloroquine phosphate-induced reproductive toxicity.

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Role of curcumin on chloroquine phosphate-induced reproductive toxicity.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Desai, Ketaki R. Dattani, Jignasa J. Rajput, Dhrupad K. Moid, Nilofar Highland, Hyacinth N. George, Linzbuoy B.
Description	Country affiliation: India Author Affiliation: Desai KR ( Department of Zoology, University School of Sciences, Gujarat University, Ahmedabad, India. ketalak60@yahoo.co.in)
Abstract	The present study was conducted to screen the efficacy of curcumin against chloroquine phosphate (CQ)-induced reproductive toxicity in adult male Swiss albino mice. Animals were given oral doses of 100, 200, 300 mg/kg body weight (b.w.), and high dose of CQ (300 mg/kg b.w.) + curcumin (80 mg/kg b.w.) for 45 days. Animals of the withdrawal group were given high dose of CQ (300 mg/kg b.w.) for 45 days and, at day 46, were kept for another 45 days. Effects were observed on some key enzymes, such as alkaline phosphatase, which was found to be decreased, whereas acid phosphatase was increased and succinate dehydrogenase and adenosine triphosphatase were decreased. Oxidative parameters, such as superoxide dismutase declined, whereas thiobarbituric acid-reactive substances were found to be elevated. Protein level was also decreased. Gravimetric indices were also recorded. Results obtained indicated adverse effects of CQ in a dose-dependent manner. The presence of curcumin with CQ alleviated its toxic effects. Hence, it can be concluded that curcumin has beneficial influences and appears able to ameliorate CQ toxicity.
File Format	HTM / HTML
ISSN	01480545
Issue Number	2
Volume Number	35
e-ISSN	15256014
Journal	Drug and Chemical Toxicology
Language	English
Publisher	Taylor & Francis
Publisher Date	2012-04-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Toxicology Antimalarials Toxicity Chloroquine Analogs & Derivatives Curcumin Pharmacology Enzyme Inhibitors Testis Drug Effects Acid Phosphatase Metabolism Adenosine Triphosphatases Alkaline Phosphatase Animals Dose-response Relationship, Drug Drug Interactions Male Mice Random Allocation Succinate Dehydrogenase Superoxide Dismutase Thiobarbituric Acid Reactive Substances Journal Article
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health Toxicology Pharmacology Chemical Health and Safety

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