NDLI: Protective effect of selenium on gentamicin-induced oxidative stress and nephrotoxicity in rats.

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Protective effect of selenium on gentamicin-induced oxidative stress and nephrotoxicity in rats.

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Protective effect of selenium on gentamicin-induced oxidative stress and nephrotoxicity in rats.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Randjelovic, Pavle Veljkovic, Slavimir Stojiljkovic, Nenad Velickovic, Ljubinka Sokolovic, Dusan Stoiljkovic, Milan Ilic, Ivan
Description	Author Affiliation: Randjelovic P ( Departments of Physiology, University of Nis, Nis, Serbia. pavleus@gmail.com)
Abstract	Gentamicin (GM) is a widely used antibiotic against serious, life-threatening infections, but its usefulness is limited by the development of nephrotoxicity. The present study was designed to determine the protective effect of selenium (Se) in GM-induced nephrotoxicity in rats. Experiments were done on 32 adult Wistar rats divided into four groups of 8 animals each. The GM group received gentamicin (100 mg/kg), whereas the GM+Se group received the same dose of GM and selenium (1 mg/kg) by intraperitoneal (i.p.) injections on a daily basis. Animals in the Se group, serving as a positive control, received only selenium (1 mg/kg) and the control group received saline (1 mL/day), both given i.p. All groups were treated during 8 consecutive days. Quantitative evaluation of GM-induced structural alterations and degree of functional alterations in the kidneys were performed by histopathological and biochemical analyses in order to determine potential beneficial effects of selenium coadministration with GM. GM was observed to cause a severe nephrotoxicity, which was evidenced by an elevation of serum urea and creatinine levels. The significant increases in malondialdehyde levels and protein carbonyl groups indicated that GM-induced tissue injury was mediated through oxidative reactions. On the other hand, simultaneous selenium administration protected kidney tissue against oxidative damage and the nephrotoxic effect caused by GM treatment. Exposure to GM caused necrosis of tubular epithelial cells. Necrosis of tubules was found to be prevented by selenium pretreatment. The results from our study indicate that selenium supplementation attenuates oxidative-stress-associated renal injury by reducing oxygen free radicals and lipid peroxidation in GM-treated rats.
File Format	HTM / HTML
ISSN	01480545
Issue Number	2
Volume Number	35
e-ISSN	15256014
Journal	Drug and Chemical Toxicology
Language	English
Publisher	Taylor & Francis
Publisher Date	2012-04-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Toxicology Anti-bacterial Agents Toxicity Gentamicins Kidney Drug Effects Oxidative Stress Sodium Selenite Pharmacology Animals Creatinine Blood Histocytochemistry Metabolism Male Malondialdehyde Protein Carbonylation Random Allocation Rats Rats, Wistar Urea Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health Toxicology Pharmacology Chemical Health and Safety

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