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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ekici, Ozlem Derinbay Isik, Nermin |
| Description | Country affiliation: Turkey Author Affiliation: Ekici OD ( Department of Parasitology, Faculty of Veterinary Medicine, University of Selcuk, Konya, Turkey. oderinbay@selcuk.edu.tr) |
| Abstract | The aim of this study was to determine the safety of imidocarb dipropionate in sheep. Imidocarb dipropionate (IMDP) was administered (2.4 mg/kg, intramuscular; i.m.) to 10 sheep, and blood samples were obtained 0, 1, 6, and 9 days after treatment. Hemacell counts, serum biochemical values, coagulation values, and serum oxidative status were measured. IMDP caused transient decreases in pH, actual bicarbonate, standard bicarbonate, total carbon dioxide, base excess in vivo, base excess in vitro, oxygen saturation, lactate dehydrogenase, and retinol levels and transient increases in serum creatine kinase-MB, blood urea nitrogen, and creatinine levels. IMDP decreased adenosine deaminase activity, antithrombin III, and superoxide dismutase activity and increased white blood cell counts. In conclusion, IMDP may change serum oxidative status and cause coagulation disorders during treatment in sheep. |
| File Format | HTM / HTML |
| ISSN | 01480545 |
| Issue Number | 2 |
| Volume Number | 35 |
| e-ISSN | 15256014 |
| Journal | Drug and Chemical Toxicology |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2012-04-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Toxicology Antiprotozoal Agents Pharmacology Imidocarb Analogs & Derivatives Sheep Blood Alanine Transaminase Alkaline Phosphatase Animals Administration & Dosage Antithrombin Iii Metabolism Aspartate Aminotransferases Blood Cell Count Veterinary Blood Gas Analysis Blood Urea Nitrogen Cholesterol Creatine Kinase Fibrinogen Hematocrit Hemoglobins L-lactate Dehydrogenase Malondialdehyde Gamma-glutamyltransferase Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health Toxicology Pharmacology Chemical Health and Safety |
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