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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Buyukleyla, Mehmet Rencuzogullari, Eyyup |
| Description | Country affiliation: Turkey Author Affiliation: Buyukleyla M ( Department of Biology, Natural and Applied Science Institute, Cukurova University, 01330 Adana, Turkey.) |
| Abstract | The genotoxic effects of thymol were investigated in human peripheral lymphocytes treated with 25, 50, 75, and 100 microg/ml concentrations of thymol for 24 and 48h treatment periods by using sister chromatid exchange (SCE), chromosome aberration (CA), and micronucleus (MN) tests. Nuclear division index (NDI), replication index (RI), and mitotic index (MI) were also calculated in order to determine the cytotoxicity of thymol. Thymol significantly increased the SCE, especially at the lower concentrations. Thymol also increased the SCE at the highest concentrations without statistical significance. Thymol induced both the structural CA and frequency of MN at all concentrations. Thymol dose-dependently decreased the NDI for two treatment periods. Thymol decreased the RI for the 24h treatment time without any statistical significance. However, thymol decreased the RI for the 48h treatment time in a dose-dependent manner. Thymol also decreased the MI at the higher concentration without dose-dependent effect. |
| File Format | HTM / HTML |
| ISSN | 01476513 |
| Issue Number | 3 |
| Volume Number | 72 |
| e-ISSN | 10902414 |
| Journal | Ecotoxicology and Environmental Safety |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2009-03-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Sciences Chromosome Aberrations Chemically Induced Lymphocytes Drug Effects Micronuclei, Chromosome-defective Mutagens Toxicity Sister Chromatid Exchange Thymol Adult Dna Damage Dose-response Relationship, Drug Female Humans Male Mutagenicity Tests Young Adult Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pollution Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health |
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