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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Türkez, Hasan Aydin, Elanur |
| Description | Country affiliation: Turkey Author Affiliation: Türkez H ( Department of Molecular Biology and Genetics, Faculty of Science, Erzurum Technical University, Erzurum, Turkey.); Aydin E ( Department of Biology, Faculty of Science, Atatürk University, Erzurum, Turkey elanuraydinn@gmail.com.) |
| Abstract | -Pinene ( -pinene), a bicyclic monoterpene, is present in the oils of many species of coniferous trees, most notably the pine, and is known for its diverse biological properties such as antimicrobial, anti-inflammatory, antiproliferative and antioxidant. However, there are limited data on the cytogenetic and antioxidant effects of -pinene in cultured human blood cells (n = 5) for the first time. The purpose of this study was to investigate the genetic, oxidative, and cytotoxic effects of -pinene in cultured human blood cells (n = 5) for the first time. Human blood cells were treated with -pinene (0 to 200 mg/L) for 24 and 48 h, and then cytotoxicity was detected by lactate dehydrogenase (LDH) release and (3-(4,5-dimethyl-thiazol-2-yl) 2,5-diphenyltetrazolium bromide) (MTT) assay, while DNA damage was also analyzed by micronucleus (MN) assay, chromosomal aberration (CA) assay and 8-oxo-2-deoxyguanosine (8-OH-dG). In addition, biochemical parameters (total antioxidant capacity (TAC) and total oxidative stress (TOS)) were examined to determine oxidative effects. The results of LDH and MTT assays showed that -pinene (at 200 mg/L) decreased cell viability. In our in vitro test systems, it was observed that -pinene did not cause any statistically important changes in the rates of studied genotoxicity endpoints but dose-dependent alterations were observed in TAC and TOS levels. -Pinene treatment caused increases in TAC levels (at 25 and 50 mg/L) and decreases in TOS levels (only at 200 mg/L) on human lymphocytes. In conclusion, the findings of the present study confirm for the first time that -pinene could be a significant source of natural antioxidant compound that may have beneficial health effects. |
| File Format | HTM / HTML |
| ISSN | 07482337 |
| Issue Number | 1 |
| Volume Number | 32 |
| e-ISSN | 14770393 |
| Journal | Toxicology and Industrial Health |
| Language | English |
| Publisher | Sage Publications |
| Publisher Date | 2016-01-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Occupational Medicine Discipline Toxicology Lymphocytes Drug Effects Monoterpenes Toxicity Oxidative Stress Antioxidants Pharmacology Cell Survival Cells, Cultured Dna Damage Humans L-lactate Dehydrogenase Metabolism Cytology Micronucleus Tests Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health Toxicology |
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