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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Colín-Barenque, Laura Pedraza-Chaverri, Jose Medina-Campos, Omar Jimenez-Martínez, Ruben Bizarro-Nevares, Patricia González-Villalva, Adriana Rojas-Lemus, Marcela Fortoul, Teresa I. |
| Description | Author Affiliation: Colín-Barenque L ( Department of Neuroscience, FES Iztacala Edo de México, México. UNAM barenque@unam.mx.); Pedraza-Chaverri J ( Department of Biology, Facultad de Química, Ciudad Universitaria México, D.F., Mexico. UNAM.); Medina-Campos O ( Department of Biology, Facultad de Química, Ciudad Universitaria México, D.F., Mexico. UNAM.); Jimenez-Martínez R ( Departament of Cellular and Tissular Biology, School of Medicine, México D.F., Mexico. UNAM.); Bizarro-Nevares P ( Departament of Cellular and Tissular Biology, School of Medicine, México D.F., Mexico. UNAM.); González-Villalva A ( Departament of Cellular and Tissular Biology, School of Medicine, México D.F., Mexico. UNAM.); Rojas-Lemus M ( Departament of Cellular and Tissular Biology, School of Medicine, México D.F., Mexico. UNAM.); Fortoul TI ( Departament of Cellular and Tissular Biology, School of Medicine, México D.F., Mexico. UNAM.) |
| Abstract | Neurodegenerative disorders, such as Parkinson's and Alzheimer's diseases, have olfaction impairment. These pathologies have also been linked to environmental pollutants. Vanadium is a pollutant, and its toxic mechanisms are related to the production of oxidative stress. In this study, we evaluated the effects of inhaled vanadium on olfaction, the olfactory bulb antioxidant, through histological and ultrastructural changes in granule cells. Mice in control group were made to inhale saline; the experimental group inhaled 0.02-M vanadium pentoxide (V2O5) for 1 hr twice a week for 4 weeks. Animals were sacrificed at 1, 2, 3, and 4 weeks after inhalation. Olfactory function was evaluated by the odorant test. The activity of glutathione peroxidase (GPx) and glutathione reductase (GR) was assayed in olfactory bulbs and processed for rapid Golgi method and ultrastructural analysis. Results show that olfactory function decreased at 4-week vanadium exposure; granule cells showed a decrease in dendritic spine density and increased lipofuscin, Golgi apparatus vacuolation, apoptosis, and necrosis. The activity of GPx and GR in the olfactory bulb was increased compared to that of the controls. Our results demonstrate that vanadium inhalation disturbs olfaction, histology, and the ultrastructure of the granule cells that might be associated with oxidative stress, a risk factor in neurodegenerative diseases. |
| File Format | HTM / HTML |
| ISSN | 01926233 |
| Issue Number | 2 |
| Volume Number | 43 |
| e-ISSN | 15331601 |
| Journal | Toxicologic Pathology |
| Language | English |
| Publisher | Sage Publications |
| Publisher Date | 2015-02-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Toxicology Discipline Pathology Environmental Pollutants Toxicity Olfactory Bulb Metabolism Pathology Vanadium Compounds Administration & Dosage Administration, Inhalation Animals Antioxidants Apoptosis Drug Effects Dendritic Spines Glutathione Peroxidase Glutathione Reductase Male Mice Necrosis Smell Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Molecular Biology Toxicology Pathology and Forensic Medicine |
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