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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | González-Villalva, Adriana Piñón-Zárate, Gabriela De la Peña Díaz, Aurora Flores-García, Mirthala Bizarro-Nevares, Patricia Rendón-Huerta, Erika P. Colín-Barenque, Laura Fortoul, Teresa Imelda |
| Description | Country affiliation: Mexico Author Affiliation: González-Villalva A ( Departamento de Biología Celular y Tisular, Facultad de Medicina, Universidad Nacional Autonoma de Mexico, CP 04510, Mexico City, Mexico. hemadgovi@yahoo.com.mx) |
| Abstract | Vanadium pentoxide (V(2)O(5)) inhalation effect on platelet function in mice was explored, as well as the in vitro effect on human platelets. Mouse blood samples were collected and processed for aggregometry and flow cytometry to assess the presence of P-selectin and monocyte-platelet conjugates. Simultaneously, human platelets were processed for aggregometry(.) The mouse results showed platelet aggregation inhibition in platelet-rich-plasma (PRP) at four-week exposure time, and normality returned at eight weeks of exposure, remaining unchanged after the exposure was discontinued after four weeks. This platelet aggregation inhibition effect was reinforced with the in vitro assay. In addition, P-selectin preserved their values during the exposure, until the exposure was discontinued during four weeks, when this activation marker increased. We conclude that vanadium affects platelet function, but further studies are required to evaluate its effect on other components of the hemostatic system. |
| File Format | HTM / HTML |
| ISSN | 13826689 |
| Issue Number | 3 |
| Volume Number | 32 |
| e-ISSN | 18727077 |
| Journal | Environmental Toxicology and Pharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2011-11-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Health Discipline Pharmacology Blood Platelets Drug Effects Physiology Vanadium Compounds Toxicity Administration, Inhalation Air Pollutants Blood Animals Cells, Cultured Humans Male Mice Mice, Inbred Strains P-selectin Metabolism Platelet Activation Platelet Aggregation Platelet-rich Plasma Administration & Dosage Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology |
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